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@ARTICLE{Hildebrandt:861576,
      author       = {Hildebrandt, Caroline S. and Helmbold, Katrin and Linden,
                      Maike and Langen, Karl-Josef and Filss, C. P. and Runions,
                      Kevin C. and Stewart, Richard M. and Rao, Pradeep and Moore,
                      Julie K. and Mahfouda, Simone and Morandini, Hugo A. E. and
                      Wong, Janice W. Y. and Rink, Lothar and Zepf, Florian D.},
      title        = {{N}o detectable effects of acute tryptophan depletion on
                      short-term immune system cytokine levels in healthy adults},
      journal      = {The world journal of biological psychiatry},
      volume       = {20},
      number       = {5},
      issn         = {1814-1412},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {FZJ-2019-02027},
      pages        = {416-423},
      year         = {2019},
      abstract     = {Objectives: Recent research suggested an influence of
                      diminished central nervous serotonin (5-HT) synthesis on the
                      leptin axis via immunological mechanisms in healthy adult
                      females. However, studies assessing immunological parameters
                      in combination with dietary challenge techniques that impact
                      brain 5-HT synthesis in humans are lacking. Methods: In
                      the present trial, a pilot analysis was conducted on data
                      obtained in healthy adult humans receiving either different
                      dietary acute tryptophan depletion (ATD) challenge or
                      tryptophan (TRP)-balanced control conditions (BAL) to study
                      the effects of reduced central nervous 5-HT synthesis on
                      serum tumor necrosis factor α (TNF-α), interleukin-1β
                      (IL-1β) and IL-6 concentrations. The data of N = 35
                      healthy adults were analysed who were randomly subjected to
                      one of the following two dietary conditions in a
                      double-blind between-subject approach: (1) The Moja-De ATD
                      challenge (ATD), or (2) TRP-balanced control condition for
                      ATD Moja-De (BAL). Serum concentrations for the assessment
                      of relevant parameters (TNF-α, IL-1β and IL-6) and
                      relevant TRP-related characteristics after the respective
                      challenge procedures were assessed at baseline (T0) and in
                      hourly intervals after administration over a period of 6 h
                      (T1–T6). Results: The ATD condition did not result in
                      significant changes to cytokine concentrations for the
                      entire study sample, or in male and female subgroups.
                      Depletion of CNS 5-HT via dietary TRP depletion appears to
                      have no statistically significant short-term impact on
                      cytokine concentrations in healthy adults. Conclusions:
                      Future research on immunological stressors in combination
                      with challenge techniques will be of value in order to
                      further disentangle the complex interplay between brain 5-HT
                      synthesis and immunological pathways.},
      cin          = {JARA-BRAIN / INM-4},
      ddc          = {610},
      cid          = {$I:(DE-82)080010_20140620$ / I:(DE-Juel1)INM-4-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29353534},
      UT           = {WOS:000476565200008},
      doi          = {10.1080/15622975.2018.1428357},
      url          = {https://juser.fz-juelich.de/record/861576},
}