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| 001 | 861576 | ||
| 005 | 20210130000855.0 | ||
| 024 | 7 | _ | |a 10.1080/15622975.2018.1428357 |2 doi |
| 024 | 7 | _ | |a 1562-2975 |2 ISSN |
| 024 | 7 | _ | |a 1814-1412 |2 ISSN |
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| 037 | _ | _ | |a FZJ-2019-02027 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Hildebrandt, Caroline S. |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a No detectable effects of acute tryptophan depletion on short-term immune system cytokine levels in healthy adults |
| 260 | _ | _ | |a Abingdon |c 2019 |b Taylor & Francis Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1565270466_18550 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Objectives: Recent research suggested an influence of diminished central nervous serotonin (5-HT) synthesis on the leptin axis via immunological mechanisms in healthy adult females. However, studies assessing immunological parameters in combination with dietary challenge techniques that impact brain 5-HT synthesis in humans are lacking. Methods: In the present trial, a pilot analysis was conducted on data obtained in healthy adult humans receiving either different dietary acute tryptophan depletion (ATD) challenge or tryptophan (TRP)-balanced control conditions (BAL) to study the effects of reduced central nervous 5-HT synthesis on serum tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β) and IL-6 concentrations. The data of N = 35 healthy adults were analysed who were randomly subjected to one of the following two dietary conditions in a double-blind between-subject approach: (1) The Moja-De ATD challenge (ATD), or (2) TRP-balanced control condition for ATD Moja-De (BAL). Serum concentrations for the assessment of relevant parameters (TNF-α, IL-1β and IL-6) and relevant TRP-related characteristics after the respective challenge procedures were assessed at baseline (T0) and in hourly intervals after administration over a period of 6 h (T1–T6). Results: The ATD condition did not result in significant changes to cytokine concentrations for the entire study sample, or in male and female subgroups. Depletion of CNS 5-HT via dietary TRP depletion appears to have no statistically significant short-term impact on cytokine concentrations in healthy adults. Conclusions: Future research on immunological stressors in combination with challenge techniques will be of value in order to further disentangle the complex interplay between brain 5-HT synthesis and immunological pathways. |
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| 700 | 1 | _ | |a Helmbold, Katrin |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Linden, Maike |0 P:(DE-HGF)0 |b 2 |
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| 700 | 1 | _ | |a Filss, C. P. |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Runions, Kevin C. |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Stewart, Richard M. |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Rao, Pradeep |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Moore, Julie K. |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Mahfouda, Simone |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Morandini, Hugo A. E. |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Wong, Janice W. Y. |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Rink, Lothar |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Zepf, Florian D. |0 P:(DE-HGF)0 |b 13 |
| 773 | _ | _ | |a 10.1080/15622975.2018.1428357 |g p. 1 - 8 |0 PERI:(DE-600)2170223-8 |n 5 |p 416-423 |t The world journal of biological psychiatry |v 20 |y 2019 |x 1814-1412 |
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