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@ARTICLE{Filss:861577,
      author       = {Filss, Christian and Heinzel, Alexander and Miiller,
                      Berthold and Vogg, Andreas and Langen, Karl-Josef and
                      Mottaghy, Felix},
      title        = {{R}elevant tumor sink effect in prostate cancer patients
                      receiving 177{L}u-{PSMA}-617 radioligand therapy},
      journal      = {Nuklearmedizin},
      volume       = {57},
      number       = {01},
      issn         = {2567-6407},
      address      = {Stuttgart},
      publisher    = {Thieme},
      reportid     = {FZJ-2019-02028},
      pages        = {19 - 25},
      year         = {2018},
      abstract     = {Aim: In metastatic prostate cancer patients PSMA targeting
                      radioligands have gained significant impact as theranostic
                      probes. In this study a correlation between total tumor
                      volume (TTV) and measured kidney dose as well as salivary
                      glands (SG) uptake in 177Lu-PSMA-617 therapy was
                      evaluated.Methods: Eleven consecutive prostate cancer
                      patients receiving a first cylcle of 177Lu-PSMA-617
                      (administered activity of approximately 6GBq) were included.
                      The 68Ga-PSMA-11 PET/CT scan previous to therapy was used to
                      determine TTV and SG uptake (glandulae submandibularis)
                      employing PMOD version 3.403 with different 68Ga-PSMA-11
                      thresholds based on the standardized uptake value (SUV).The
                      kidney dose was estimated with the software ULMDOS using
                      planar whole-body scintigrams.Results: Kidney dose and SG
                      uptake was inversely correlated to TTV, indicating high
                      kidney dose and high SG uptake in case of low tumor load and
                      low kidney dose and low SG uptake in case of high tumor
                      load.Conclusion: Our data support the hypothesis that in
                      177Lu-PSMA-617 therapy an individualized treatment activity
                      based on total tumor volume could be beneficiary.},
      cin          = {JARA-BRAIN / INM-4},
      ddc          = {610},
      cid          = {$I:(DE-82)080010_20140620$ / I:(DE-Juel1)INM-4-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29536496},
      UT           = {WOS:000426117600004},
      doi          = {10.3413/Nukmed-0937-17-10},
      url          = {https://juser.fz-juelich.de/record/861577},
}