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@ARTICLE{Gras:861672,
      author       = {Gras, Vincent and Farrher, Ezequiel and Grinberg, Farida
                      and Shah, N. J.},
      title        = {{D}iffusion-weighted {DESS} protocol optimization for
                      simultaneous mapping of the mean diffusivity, proton density
                      and relaxation times at 3 {T}esla},
      journal      = {Magnetic resonance in medicine},
      volume       = {78},
      number       = {1},
      issn         = {0740-3194},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2019-02109},
      pages        = {130 - 141},
      year         = {2017},
      abstract     = {PurposeTo design a general framework for the optimization
                      of an MRI protocol based on the the diffusion‐weighted
                      dual‐echo steady‐state (DW‐DESS) sequence, enabling
                      quantitative and simultaneous mapping of proton density
                      (PD), relaxation times
                      urn:x-wiley:07403194:media:mrm26353:mrm26353-math-0001 and
                      urn:x-wiley:07403194:media:mrm26353:mrm26353-math-0002 and
                      diffusion coefficient D.MethodsA parameterization of the
                      DW‐DESS sequence minimizing the Cramér‐Rao lower bound
                      of each parameter estimate was proposed and tested in a
                      phantom experiment. An extension of the protocol was
                      implemented for brain imaging to return the rotationally
                      invariant mean diffusivity (MD).ResultsIn an NiCl2‐doped
                      agar gel phantom wherein
                      urn:x-wiley:07403194:media:mrm26353:mrm26353-math-0003 ms,
                      the parameter estimation errors were below $3\%$ for PD and
                      urn:x-wiley:07403194:media:mrm26353:mrm26353-math-0004 and
                      below $7\%$ for
                      urn:x-wiley:07403194:media:mrm26353:mrm26353-math-0005 and D
                      while the measured signal‐to‐noise ratio always exceeded
                      20. In the human brain, the in vivo parametric maps obtained
                      were overall in reasonable agreement with gold standard
                      measurements, despite a broadening of the distributions due
                      to physiological motion.ConclusionWithin the optimization
                      framework presented here, DW‐DESS images can be
                      quantitatively interpreted to yield four intrinsic
                      parameters of the tissue. Currently, the method is limited
                      by the sensitivity of the DW‐DESS sequence in terms of
                      physiological motion. Magn Reson Med 78:130–141, 2017. ©
                      2016 International Society for Magnetic Resonance in
                      Medicine},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27476684},
      UT           = {WOS:000403803900013},
      doi          = {10.1002/mrm.26353},
      url          = {https://juser.fz-juelich.de/record/861672},
}