TY  - JOUR
AU  - Stegmayr, Carina
AU  - Willuweit, Antje
AU  - Lohmann, Philipp
AU  - Langen, Karl-Josef
TI  - O‑(2‑[18F]‑fluoroethyl)-L‑tyrosine (FET) in neurooncology: A review of experimental results
JO  - Current radiopharmaceuticals
VL  - 12
IS  - 3
SN  - 1874-4710
CY  - Sharjah
PB  - Bentham Science Publ.
M1  - FZJ-2019-02119
SP  - 201-210
PY  - 2019
AB  - In recent years, PET using radiolabelled amino acids has gained considerable interest as an additional tool besides MRI to improve the diagnosis of cerebral gliomas and brain metastases. A very successful tracer in this field is O-(2-[18F]fluoroethyl)-L-tyrosine (FET) which in recent years has replaced short-lived tracers such as [11C]-methyl-L-methionine in many neuro-oncological centers in Western Europe. FET can be produced with high efficiency and distributed in a satellite concept like 2- [18F]fluoro-2-deoxy-D-glucose. Many clinical studies have demonstrated that FET PET provides important diagnostic information regarding the delineation of cerebral gliomas for therapy planning, an improved differentiation of tumor recurrence from treatment-related changes and sensitive treatment monitoring. In parallel, a considerable number of experimental studies have investigated the uptake mechanisms of FET on the cellular level and the behavior of the tracer in various benign lesions in order to clarify the specificity of FET uptake for tumor tissue. Further studies have explored the effects of treatment related tissue alterations on tracer uptake such as surgery, radiation and drug therapy. Finally, the role of blood-brain barrier integrity for FET uptake which presents an important aspect for PET tracers targeting neoplastic lesions in the brain has been investigated in several studies. Based on a literature research regarding experimental FET studies and corresponding clinical applications this article summarizes the knowledge on the uptake behavior of FET, which has been collected in more than 30 experimental studies during the last two decades and discusses the role of these results in the clinical context. 
LB  - PUB:(DE-HGF)16
C6  - pmid:30636621
UR  - <Go to ISI:>//WOS:000488749800003
DO  - DOI:10.2174/1874471012666190111111046
UR  - https://juser.fz-juelich.de/record/861682
ER  -