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@ARTICLE{Lenssen:861744,
      author       = {Lenssen, R. and Schmitz, K. and Griesel, C. and
                      Heidenreich, A. and Schulz, Jörg B. and Trautwein, C. and
                      Marx, N. and Fitzner, C. and Jaehde, U. and Eisert, A.},
      title        = {{C}omprehensive pharmaceutical care to prevent drug-related
                      readmissions of dependent-living elderly patients: a
                      randomized controlled trial},
      journal      = {BMC geriatrics},
      volume       = {18},
      number       = {1},
      issn         = {1471-2318},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2019-02172},
      pages        = {135},
      year         = {2018},
      abstract     = {BackgroundElderly patients are vulnerable to adverse drug
                      reactions (ADRs). Drug-related readmissions (DRRs) can be a
                      major consequence of ADR. Therefore, this study aimed to
                      investigate the effects of a ward-based, comprehensive
                      pharmaceutical care service on the occurrence of DRRs as the
                      endpoint in dependent-living elderly patients.MethodsA
                      randomized, controlled trial was performed at a German
                      University Hospital. Patients fulfilling the following
                      criteria were eligible: admission to a cooperating ward,
                      existing drug therapy at admission, 65 years of age and
                      older, home-care or nursing home residents in ambulatory
                      care, and a minimum hospital stay of three days. Patients
                      received either standard care (control group) or
                      pharmaceutical care (intervention group). Follow-up
                      consultations were conducted for each patient at 1, 8, 26,
                      and 52 weeks after discharge. The time to DRR was defined as
                      the primary outcome measure and was analysed using the
                      log-rank test. The Cox-proportional hazard model was used
                      for risk factor analysis.ResultsSixty patients (n = 31
                      intervention group, n = 29 control group) participated
                      in the study. For patients in the intervention group, the
                      median time to DRR was prolonged; however, the level of
                      statistical significance was not reached (log-rank test
                      P = 0.068; HR = 3.28, P = 0.086). When the risk
                      factors ‘age’ or ‘length of stay on the ward’ were
                      added to the Cox proportional hazard model, patients in the
                      control group exhibited a significantly higher risk of
                      experiencing a DRR than patients of the intervention group
                      (HR = 4.62; P = 0.028 including age and
                      HR = 5.76; P = 0.033 including length of stay on the
                      ward).ConclusionsOur findings demonstrate the successful
                      implementation of ward-based, comprehensive pharmaceutical
                      care for dependent-living elderly. Despite a low
                      participation rate, which led to an underpowered study, the
                      results provide a preliminary efficacy signal and effect
                      size estimates to power a definitive trial.},
      cin          = {INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-11-20170113},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29898670},
      UT           = {WOS:000435391600004},
      doi          = {10.1186/s12877-018-0814-3},
      url          = {https://juser.fz-juelich.de/record/861744},
}