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000861855 1001_ $$0P:(DE-HGF)0$$aAmundarain, María Julia$$b0
000861855 245__ $$aGABA A receptor family: overview on structural characterization
000861855 260__ $$aLondon$$bFuture Science$$c2019
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000861855 520__ $$aThe pentameric γ-aminobutyric acid type A receptors are ion channels activated by ligands, which intervene in the rapid inhibitory transmission in the mammalian CNS. Due to their rich pharmacology and therapeutic potential, it is essential to understand their structure and function thoroughly. This deep characterization was hampered by the lack of experimental structural information for many years. Thus, computational techniques have been extensively combined with experimental data, in order to undertake the study of γ-aminobutyric acid type A receptors and their interaction with drugs. Here, we review the exciting journey made to assess the structures of these receptors and outline major outcomes. Finally, we discuss the brand new structure of the α1β2γ2 subtype and the amazing advances it brings to the field.
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000861855 7001_ $$0P:(DE-HGF)0$$aRibeiro, Rui Pedro$$b1
000861855 7001_ $$0P:(DE-HGF)0$$aCostabel, Marcelo Daniel$$b2
000861855 7001_ $$0P:(DE-Juel1)165199$$aGiorgetti, Alejandro$$b3$$eCorresponding author
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