TY  - JOUR
AU  - Amundarain, María Julia
AU  - Ribeiro, Rui Pedro
AU  - Costabel, Marcelo Daniel
AU  - Giorgetti, Alejandro
TI  - GABA A receptor family: overview on structural characterization
JO  - Future medicinal chemistry
VL  - 11
IS  - 3
SN  - 1756-8927
CY  - London
PB  - Future Science
M1  - FZJ-2019-02276
SP  - 229 - 245
PY  - 2019
AB  - The pentameric γ-aminobutyric acid type A receptors are ion channels activated by ligands, which intervene in the rapid inhibitory transmission in the mammalian CNS. Due to their rich pharmacology and therapeutic potential, it is essential to understand their structure and function thoroughly. This deep characterization was hampered by the lack of experimental structural information for many years. Thus, computational techniques have been extensively combined with experimental data, in order to undertake the study of γ-aminobutyric acid type A receptors and their interaction with drugs. Here, we review the exciting journey made to assess the structures of these receptors and outline major outcomes. Finally, we discuss the brand new structure of the α1β2γ2 subtype and the amazing advances it brings to the field.
LB  - PUB:(DE-HGF)16
C6  - pmid:30801199
UR  - <Go to ISI:>//WOS:000465356900007
DO  - DOI:10.4155/fmc-2018-0336
UR  - https://juser.fz-juelich.de/record/861855
ER  -