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@ARTICLE{Amundarain:861855,
      author       = {Amundarain, María Julia and Ribeiro, Rui Pedro and
                      Costabel, Marcelo Daniel and Giorgetti, Alejandro},
      title        = {{GABA} {A} receptor family: overview on structural
                      characterization},
      journal      = {Future medicinal chemistry},
      volume       = {11},
      number       = {3},
      issn         = {1756-8927},
      address      = {London},
      publisher    = {Future Science},
      reportid     = {FZJ-2019-02276},
      pages        = {229 - 245},
      year         = {2019},
      abstract     = {The pentameric γ-aminobutyric acid type A receptors are
                      ion channels activated by ligands, which intervene in the
                      rapid inhibitory transmission in the mammalian CNS. Due to
                      their rich pharmacology and therapeutic potential, it is
                      essential to understand their structure and function
                      thoroughly. This deep characterization was hampered by the
                      lack of experimental structural information for many years.
                      Thus, computational techniques have been extensively
                      combined with experimental data, in order to undertake the
                      study of γ-aminobutyric acid type A receptors and their
                      interaction with drugs. Here, we review the exciting journey
                      made to assess the structures of these receptors and outline
                      major outcomes. Finally, we discuss the brand new structure
                      of the α1β2γ2 subtype and the amazing advances it brings
                      to the field.},
      cin          = {IAS-5 / INM-9},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121},
      pnm          = {574 - Theory, modelling and simulation (POF3-574)},
      pid          = {G:(DE-HGF)POF3-574},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30801199},
      UT           = {WOS:000465356900007},
      doi          = {10.4155/fmc-2018-0336},
      url          = {https://juser.fz-juelich.de/record/861855},
}