TY  - JOUR
AU  - Poeppl, Timm B.
AU  - Langguth, Berthold
AU  - Laird, Angela R.
AU  - Eickhoff, Simon
TI  - Meta-analytic Evidence for Neural Dysactivity Underlying Sexual Dysfunction
JO  - The journal of sexual medicine
VL  - 16
IS  - 5
SN  - 1743-6095
CY  - [London]
PB  - Elsevier
M1  - FZJ-2019-02360
SP  - 614–617
PY  - 2019
N1  - Funding: Angela R. Laird was supported by awards from the National Institutes of Mental Health (U01 DA041156 and R01 DA041353) and the National Science Foundation (1631325 and CNS 1532061). Simon B. Eickhoff was supported by the Deutsche Forschungsgemeinschaft (DFG; EI 816/4–1, EI 816/6–1), the National Institute of Mental Health (R01 MH074457), the Helmholtz Portfolio Theme "Supercomputing and Modeling for the Human Brain" and the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No. 7202070 (HBP SGA1).
AB  - About 30-40% of the population report sexual dysfunction. Although it is well known that the brain controls sexual behavior, little is known about the neural basis of sexual dysfunction.AIM:To assess convergence of altered brain activity associated with sexual dysfunction across available functional imaging studies.METHODS:We used activation likelihood estimation meta-analysis to quantify interstudy concordance across 14 functional imaging studies reporting 179 foci from 40 individual analyses involving 191 subjects with sexual dysfunction and 123 controls.MAIN OUTCOME MEASURE:Activation likelihood estimation scores were used to assess convergence of findings.RESULTS:Consistently decreased brain activity associated with sexual dysfunction was identified in the dorsal anterior cingulate cortex, ventral striatum, dorsal midbrain, anterior midcingulate cortex, and lateral orbitofrontal cortex.CLINICAL IMPLICATION:These findings can serve as a basis for further studies on the pathophysiology of this highly common disorder with the view to development of more-specific treatment strategies.STRENGTH & LIMITATIONS:Findings are based on an observer-independent meta-analysis that provides robust evidence for and anatomic localization of altered brain activity related to sexual dysfunction. Our analysis cannot distinguish between the putative sources of sexual dysfunction, but it provides a more ubiquitous and general pattern of related altered neural activity.CONCLUSION:The identified regions have previously been shown to be critically involved in mediating sexual arousal and to be part of the sympathetic division of the autonomic nervous system. This suggests that the disturbance of brain activity associated with sexual dysfunction primarily affects sexual arousal already at early stages that are controlled by the sympathetic nervous system. Poeppl TB, Langguth B, Laird AR, et al. Meta-analytic Evidence for Neural Dysactivity Underlying Sexual Dysfunction. J Sex Med 2019;XX:XXX-XXX.
LB  - PUB:(DE-HGF)16
C6  - pmid:30926513
UR  - <Go to ISI:>//WOS:000469936400002
DO  - DOI:10.1016/j.jsxm.2019.02.012
UR  - https://juser.fz-juelich.de/record/861955
ER  -