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@ARTICLE{Poeppl:861955,
      author       = {Poeppl, Timm B. and Langguth, Berthold and Laird, Angela R.
                      and Eickhoff, Simon},
      title        = {{M}eta-analytic {E}vidence for {N}eural {D}ysactivity
                      {U}nderlying {S}exual {D}ysfunction},
      journal      = {The journal of sexual medicine},
      volume       = {16},
      number       = {5},
      issn         = {1743-6095},
      address      = {[London]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2019-02360},
      pages        = {614–617},
      year         = {2019},
      note         = {Funding: Angela R. Laird was supported by awards from the
                      National Institutes of Mental Health (U01 DA041156 and R01
                      DA041353) and the National Science Foundation (1631325 and
                      CNS 1532061). Simon B. Eickhoff was supported by the
                      Deutsche Forschungsgemeinschaft (DFG; EI 816/4–1, EI
                      816/6–1), the National Institute of Mental Health (R01
                      MH074457), the Helmholtz Portfolio Theme "Supercomputing and
                      Modeling for the Human Brain" and the European Union's
                      Horizon 2020 Research and Innovation Programme under Grant
                      Agreement No. 7202070 (HBP SGA1).},
      abstract     = {About $30-40\%$ of the population report sexual
                      dysfunction. Although it is well known that the brain
                      controls sexual behavior, little is known about the neural
                      basis of sexual dysfunction.AIM:To assess convergence of
                      altered brain activity associated with sexual dysfunction
                      across available functional imaging studies.METHODS:We used
                      activation likelihood estimation meta-analysis to quantify
                      interstudy concordance across 14 functional imaging studies
                      reporting 179 foci from 40 individual analyses involving 191
                      subjects with sexual dysfunction and 123 controls.MAIN
                      OUTCOME MEASURE:Activation likelihood estimation scores were
                      used to assess convergence of findings.RESULTS:Consistently
                      decreased brain activity associated with sexual dysfunction
                      was identified in the dorsal anterior cingulate cortex,
                      ventral striatum, dorsal midbrain, anterior midcingulate
                      cortex, and lateral orbitofrontal cortex.CLINICAL
                      IMPLICATION:These findings can serve as a basis for further
                      studies on the pathophysiology of this highly common
                      disorder with the view to development of more-specific
                      treatment strategies.STRENGTH $\&$ LIMITATIONS:Findings are
                      based on an observer-independent meta-analysis that provides
                      robust evidence for and anatomic localization of altered
                      brain activity related to sexual dysfunction. Our analysis
                      cannot distinguish between the putative sources of sexual
                      dysfunction, but it provides a more ubiquitous and general
                      pattern of related altered neural activity.CONCLUSION:The
                      identified regions have previously been shown to be
                      critically involved in mediating sexual arousal and to be
                      part of the sympathetic division of the autonomic nervous
                      system. This suggests that the disturbance of brain activity
                      associated with sexual dysfunction primarily affects sexual
                      arousal already at early stages that are controlled by the
                      sympathetic nervous system. Poeppl TB, Langguth B, Laird AR,
                      et al. Meta-analytic Evidence for Neural Dysactivity
                      Underlying Sexual Dysfunction. J Sex Med 2019;XX:XXX-XXX.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572) / SMHB -
                      Supercomputing and Modelling for the Human Brain
                      (HGF-SMHB-2013-2017) / HBP SGA1 - Human Brain Project
                      Specific Grant Agreement 1 (720270)},
      pid          = {G:(DE-HGF)POF3-572 / G:(DE-Juel1)HGF-SMHB-2013-2017 /
                      G:(EU-Grant)720270},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30926513},
      UT           = {WOS:000469936400002},
      doi          = {10.1016/j.jsxm.2019.02.012},
      url          = {https://juser.fz-juelich.de/record/861955},
}