TY  - JOUR
AU  - Li, Changhong
AU  - Fronczek‐Poncelet, Judith
AU  - Lange, Denise
AU  - Hennecke, Eva
AU  - Kroll, Tina
AU  - Matusch, Andreas
AU  - Aeschbach, Daniel
AU  - Bauer, Andreas
AU  - Elmenhorst, Eva‐Maria
AU  - Elmenhorst, David
TI  - Impact of acute sleep deprivation on dynamic functional connectivity states
JO  - Human brain mapping
VL  - 41
IS  - 4
SN  - 1047-3211
CY  - New York, NY
PB  - Wiley-Liss
M1  - FZJ-2019-02411
SP  - 994-1005
PY  - 2020
AB  - Sleep deprivation (SD) could amplify the temporal fluctuation of spontaneous brain activities that reflect different arousal levels using a dynamic functional connectivity (dFC) approach. Therefore, we intended to evaluate the test–retest reliability of dFC characteristics during rested wakefulness (RW), and to explore how the properties of these dynamic connectivity states were affected by extended durations of acute sleep loss (28/52 hr). We acquired resting‐state fMRI and neuropsychological datasets in two independent studies: (a) twice during RW and once after 28 hr of SD (n = 15) and (b) after 52 hr of SD and after 14 hr of recovery sleep (RS; n = 14). Sliding‐window correlations approach was applied to estimate their covariance matrices and corresponding three connectivity states were generated. The test–retest reliability of dFC properties demonstrated mean dwell time and fraction of connectivity states were reliable. After SD, the mean dwell time of a specific state, featured by strong subcortical–cortical anticorrelations, was significantly increased. Conversely, another globally hypoconnected state was significantly decreased. Subjective sleepiness and objective performances were separately positive and negative correlated with the increased and decreased state. Two brain connectivity states and their alterations might be sufficiently sensitive to reflect changes in the dynamics of brain mental activities after sleep loss.
LB  - PUB:(DE-HGF)16
C6  - pmid:31680379
UR  - <Go to ISI:>//WOS:000493799800001
DO  - DOI:10.1002/hbm.24855
UR  - https://juser.fz-juelich.de/record/862045
ER  -