% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Zhang:862092,
      author       = {Zhang, Yuting and Figueroa-Miranda, Gabriela and Lyu,
                      Zhaozi and Zafiu, Christian and Willbold, Dieter and
                      Offenhäusser, Andreas and Mayer, Dirk},
      title        = {{M}onitoring amyloid-β proteins aggregation based on
                      label-free aptasensor},
      journal      = {Sensors and actuators / B Chemical : an international
                      journal devoted to research and development of chemical
                      transducers an international journal devoted to research and
                      development of chemical transducers},
      volume       = {288},
      issn         = {0925-4005},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2019-02448},
      pages        = {535 - 542},
      year         = {2019},
      abstract     = {Amyloid-β oligomers (AβO) are important diagnostic
                      markers for Alzheimer's disease (AD) and potential
                      therapeutic targets for treating it. Herein, a simple and
                      label-free electrochemical biosensor is presented for the
                      specific recognition of AβO based on the binding of these
                      biomarkers to ssDNA aptamer receptors. The ssDNA aptamer
                      self-assembles to gold rod electrodes through Au-S
                      interactions and binds specifically to AβO. The novel
                      aptasensor shows a wide linear concentration range from 0.1
                      to 500 nM with a low detection limit of 0.03 nM as
                      derived from electrochemical impedance spectroscopy
                      invesastigations. Furthermore, owing to the high selectivity
                      among Aβ species, this label-free sensor was used to
                      monitor the process of Aβ protein aggregation, which was
                      validated by atomic force microscope analysis. In addition,
                      the aptasensor can be used to detect AβO in artificial CSF
                      with satisfying accuracy. To our knowledge, it is first
                      label-free aptasensor for an AβO assay based on EIS that
                      works in artificial CSF and can be used for monitoring Aβ
                      protein aggregation. These features, together with its easy
                      fabrication, operation convenience, and effective
                      regeneration, make our new aptasensor a promising tool for
                      the early detection of AD and drug development by monitoring
                      Aβ plaques degradation.},
      cin          = {ICS-8},
      ddc          = {620},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000462468000067},
      doi          = {10.1016/j.snb.2019.03.049},
      url          = {https://juser.fz-juelich.de/record/862092},
}