000862216 001__ 862216
000862216 005__ 20210130001226.0
000862216 037__ $$aFZJ-2019-02559
000862216 1001_ $$0P:(DE-HGF)0$$aShymanskaya, A.$$b0
000862216 1112_ $$a57. Jahrestagung der DGN$$cBremen$$d2019-04-03 - 2019-04-06$$wGermany
000862216 245__ $$aComparison of [18F]-Fluoroethyltyrosine PET and the IDH status with Sodium MRI in Cerebral Gliomas
000862216 260__ $$c2019
000862216 3367_ $$0PUB:(DE-HGF)1$$2PUB:(DE-HGF)$$aAbstract$$babstract$$mabstract$$s1554899922_3179
000862216 3367_ $$033$$2EndNote$$aConference Paper
000862216 3367_ $$2BibTeX$$aINPROCEEDINGS
000862216 3367_ $$2DRIVER$$aconferenceObject
000862216 3367_ $$2DataCite$$aOutput Types/Conference Abstract
000862216 3367_ $$2ORCID$$aOTHER
000862216 520__ $$aZiel/Aim:O-(2-[18F]fluoroethyl)-L-tyrosine([18F]-FET) PET is used for the supportive diagnostics of cerebral gliomas. In this study, the relationship between the [18F]-FET-PET parameters, distribution of restricted (mainly intracellular) and unrestricted (mainly extracellular) sodium, and the mutational status of the enzyme isocitrate dehydrogenase (IDH) were investigated in patients with cerebral gliomas.Methodik/Methods:Ten patients with untreated gliomas and one patient with a recurrent glioblastoma were investigated by dynamic [18F]-FET-PET and sodium MRI using an enhanced SISTINA sequence to estimate sodium parameters in tumours. The enhanced SISTINA sequence uses single-quantum and triple-quantum-filtered imaging and allows simultaneous acquisition of signal originating from restricted and unrestricted sodium (1). IDH mutational status was determined after biopsy or resection. The untreated patients were analysed independently in two groups (5 patients each) dependent on their IDH mutational status.Ergebnisse/Results:Tumour-to-brain ratio (TBR) of weighted mainly intracellular sodium (NaR) was significantly lower in IDH mutated (p=0.01) than in IDH wildtype gliomas. Total sodium concentration in mmol/L (p=0.05), TBR of the total sodium concentration (NaT) (p=0.02), TBR of weighted unrestricted mainly extracellular sodium (NaNR) (p=0.003), and the ratio of NaT/NaR (p<0.001) were significantly higher in IDH mutated than in IDH wildtype gliomas. [18F]-FET parameters estimated from tracer dynamics curves (TBR, time-to-peak) correlated neither to the IDH status nor to the sodium distribution. The patient with a recurrent GBM exhibited an additional radiation injury with strong abnormalities in sodium MRI.Schlussfolgerungen/Conclusions:Acquired results show that sodium MRI shows stronger relation to the IDH mutational status than [18F]-FET-PET parameters in cerebral gliomas in this patient cohort. Further evaluation of the combination of the three diagnostic modalities in gliomas seems promising and requires higher patient number.Literatur/References:[1] Worthoff WA, Shymanskaya A, Shah NJ. Relaxometry and quantification in simultaneously acquired single and triple quantum filtered sodium MRI. Magn Reson Med. 2018;00:1-13. doi:10.1002/mrm.27387.
000862216 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000862216 7001_ $$0P:(DE-Juel1)156200$$aWorthoff, W. A.$$b1$$ufzj
000862216 7001_ $$0P:(DE-Juel1)131627$$aStoffels, G.$$b2$$ufzj
000862216 7001_ $$0P:(DE-Juel1)131657$$aLindemeyer, J.$$b3$$ufzj
000862216 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, B.$$b4$$ufzj
000862216 7001_ $$0P:(DE-Juel1)145110$$aLohmann, P.$$b5$$ufzj
000862216 7001_ $$0P:(DE-Juel1)143792$$aGalldiks, N.$$b6$$ufzj
000862216 7001_ $$0P:(DE-Juel1)131777$$aLangen, K. J.$$b7$$ufzj
000862216 7001_ $$0P:(DE-Juel1)131794$$aShah, N. J.$$b8$$ufzj
000862216 8564_ $$uhttps://www.nuklearmedizin.de/jahrestagungen/abstr_online2019/abstract_search.php?navId=227
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000862216 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131627$$aForschungszentrum Jülich$$b2$$kFZJ
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000862216 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131777$$aForschungszentrum Jülich$$b7$$kFZJ
000862216 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131794$$aForschungszentrum Jülich$$b8$$kFZJ
000862216 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000862216 9141_ $$y2019
000862216 920__ $$lyes
000862216 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000862216 9201_ $$0I:(DE-Juel1)INM-4-20090406$$kINM-4$$lPhysik der Medizinischen Bildgebung$$x1
000862216 9201_ $$0I:(DE-Juel1)INM-5-20090406$$kINM-5$$lNuklearchemie$$x2
000862216 980__ $$aabstract
000862216 980__ $$aVDB
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