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@INPROCEEDINGS{Shymanskaya:862216,
      author       = {Shymanskaya, A. and Worthoff, W. A. and Stoffels, G. and
                      Lindemeyer, J. and Neumaier, B. and Lohmann, P. and
                      Galldiks, N. and Langen, K. J. and Shah, N. J.},
      title        = {{C}omparison of [18{F}]-{F}luoroethyltyrosine {PET} and the
                      {IDH} status with {S}odium {MRI} in {C}erebral {G}liomas},
      reportid     = {FZJ-2019-02559},
      year         = {2019},
      abstract     = {Ziel/Aim:O-(2-[18F]fluoroethyl)-L-tyrosine([18F]-FET) PET
                      is used for the supportive diagnostics of cerebral gliomas.
                      In this study, the relationship between the [18F]-FET-PET
                      parameters, distribution of restricted (mainly
                      intracellular) and unrestricted (mainly extracellular)
                      sodium, and the mutational status of the enzyme isocitrate
                      dehydrogenase (IDH) were investigated in patients with
                      cerebral gliomas.Methodik/Methods:Ten patients with
                      untreated gliomas and one patient with a recurrent
                      glioblastoma were investigated by dynamic [18F]-FET-PET and
                      sodium MRI using an enhanced SISTINA sequence to estimate
                      sodium parameters in tumours. The enhanced SISTINA sequence
                      uses single-quantum and triple-quantum-filtered imaging and
                      allows simultaneous acquisition of signal originating from
                      restricted and unrestricted sodium (1). IDH mutational
                      status was determined after biopsy or resection. The
                      untreated patients were analysed independently in two groups
                      (5 patients each) dependent on their IDH mutational
                      status.Ergebnisse/Results:Tumour-to-brain ratio (TBR) of
                      weighted mainly intracellular sodium (NaR) was significantly
                      lower in IDH mutated (p=0.01) than in IDH wildtype gliomas.
                      Total sodium concentration in mmol/L (p=0.05), TBR of the
                      total sodium concentration (NaT) (p=0.02), TBR of weighted
                      unrestricted mainly extracellular sodium (NaNR) (p=0.003),
                      and the ratio of NaT/NaR (p<0.001) were significantly higher
                      in IDH mutated than in IDH wildtype gliomas. [18F]-FET
                      parameters estimated from tracer dynamics curves (TBR,
                      time-to-peak) correlated neither to the IDH status nor to
                      the sodium distribution. The patient with a recurrent GBM
                      exhibited an additional radiation injury with strong
                      abnormalities in sodium
                      MRI.Schlussfolgerungen/Conclusions:Acquired results show
                      that sodium MRI shows stronger relation to the IDH
                      mutational status than [18F]-FET-PET parameters in cerebral
                      gliomas in this patient cohort. Further evaluation of the
                      combination of the three diagnostic modalities in gliomas
                      seems promising and requires higher patient
                      number.Literatur/References:[1] Worthoff WA, Shymanskaya A,
                      Shah NJ. Relaxometry and quantification in simultaneously
                      acquired single and triple quantum filtered sodium MRI. Magn
                      Reson Med. 2018;00:1-13. doi:10.1002/mrm.27387.},
      month         = {Apr},
      date          = {2019-04-03},
      organization  = {57. Jahrestagung der DGN, Bremen
                       (Germany), 3 Apr 2019 - 6 Apr 2019},
      cin          = {INM-3 / INM-4 / INM-5},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)1},
      url          = {https://juser.fz-juelich.de/record/862216},
}