%0 Journal Article
%A de Saint Victor, Marie
%A Barnsley, Lester C.
%A Carugo, Dario
%A Owen, Joshua
%A Coussios, Constantin C.
%A Stride, Eleanor
%T Sonothrombolysis with Magnetically Targeted Microbubbles
%J Ultrasound in medicine & biology
%V 45
%N 5
%@ 0301-5629
%C Amsterdam [u.a.]
%I Elsevier Science
%M FZJ-2019-02597
%P 1151 - 1163
%D 2019
%X Microbubble-enhanced sonothrombolysis is a promising approach to increasing the tolerability and efficacy of current pharmacological treatments for ischemic stroke. Maintaining therapeutic concentrations of microbubbles and drugs at the clot site, however, poses a challenge. The objective of this study was to investigate the effect of magnetic microbubble targeting upon clot lysis rates in vitro. Retracted whole porcine blood clots were placed in a flow phantom of a partially occluded middle cerebral artery. The clots were treated with a combination of tissue plasminogen activator (0.75 µg/mL), magnetic microbubbles (∼107 microbubbles/mL) and ultrasound (0.5 MHz, 630-kPa peak rarefactional pressure, 0.2-Hz pulse repetition frequency, 2% duty cycle). Magnetic targeting was achieved using a single permanent magnet (0.08–0.38 T and 12-140 T/m in the region of the clot). The change in clot diameter was measured optically over the course of the experiment. Magnetic targeting produced a threefold average increase in lysis rates, and linear correlation was observed between lysis rate and total energy of acoustic emissions.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30773375
%U <Go to ISI:>//WOS:000464126800011
%R 10.1016/j.ultrasmedbio.2018.12.014
%U https://juser.fz-juelich.de/record/862255