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000862255 1001_ $$0P:(DE-HGF)0$$ade Saint Victor, Marie$$b0$$eFirst author
000862255 245__ $$aSonothrombolysis with Magnetically Targeted Microbubbles
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000862255 520__ $$aMicrobubble-enhanced sonothrombolysis is a promising approach to increasing the tolerability and efficacy of current pharmacological treatments for ischemic stroke. Maintaining therapeutic concentrations of microbubbles and drugs at the clot site, however, poses a challenge. The objective of this study was to investigate the effect of magnetic microbubble targeting upon clot lysis rates in vitro. Retracted whole porcine blood clots were placed in a flow phantom of a partially occluded middle cerebral artery. The clots were treated with a combination of tissue plasminogen activator (0.75 µg/mL), magnetic microbubbles (∼107 microbubbles/mL) and ultrasound (0.5 MHz, 630-kPa peak rarefactional pressure, 0.2-Hz pulse repetition frequency, 2% duty cycle). Magnetic targeting was achieved using a single permanent magnet (0.08–0.38 T and 12-140 T/m in the region of the clot). The change in clot diameter was measured optically over the course of the experiment. Magnetic targeting produced a threefold average increase in lysis rates, and linear correlation was observed between lysis rate and total energy of acoustic emissions.
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000862255 7001_ $$0P:(DE-Juel1)172014$$aBarnsley, Lester C.$$b1
000862255 7001_ $$0P:(DE-HGF)0$$aCarugo, Dario$$b2
000862255 7001_ $$0P:(DE-HGF)0$$aOwen, Joshua$$b3
000862255 7001_ $$0P:(DE-HGF)0$$aCoussios, Constantin C.$$b4
000862255 7001_ $$00000-0003-3371-5929$$aStride, Eleanor$$b5$$eCorresponding author
000862255 773__ $$0PERI:(DE-600)1498918-9$$a10.1016/j.ultrasmedbio.2018.12.014$$gVol. 45, no. 5, p. 1151 - 1163$$n5$$p1151 - 1163$$tUltrasound in medicine & biology$$v45$$x0301-5629$$y2019
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