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024 7 _ |a 10.1016/j.ultrasmedbio.2018.12.014
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100 1 _ |a de Saint Victor, Marie
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245 _ _ |a Sonothrombolysis with Magnetically Targeted Microbubbles
260 _ _ |a Amsterdam [u.a.]
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520 _ _ |a Microbubble-enhanced sonothrombolysis is a promising approach to increasing the tolerability and efficacy of current pharmacological treatments for ischemic stroke. Maintaining therapeutic concentrations of microbubbles and drugs at the clot site, however, poses a challenge. The objective of this study was to investigate the effect of magnetic microbubble targeting upon clot lysis rates in vitro. Retracted whole porcine blood clots were placed in a flow phantom of a partially occluded middle cerebral artery. The clots were treated with a combination of tissue plasminogen activator (0.75 µg/mL), magnetic microbubbles (∼107 microbubbles/mL) and ultrasound (0.5 MHz, 630-kPa peak rarefactional pressure, 0.2-Hz pulse repetition frequency, 2% duty cycle). Magnetic targeting was achieved using a single permanent magnet (0.08–0.38 T and 12-140 T/m in the region of the clot). The change in clot diameter was measured optically over the course of the experiment. Magnetic targeting produced a threefold average increase in lysis rates, and linear correlation was observed between lysis rate and total energy of acoustic emissions.
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700 1 _ |a Barnsley, Lester C.
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700 1 _ |a Carugo, Dario
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700 1 _ |a Owen, Joshua
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700 1 _ |a Coussios, Constantin C.
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700 1 _ |a Stride, Eleanor
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773 _ _ |a 10.1016/j.ultrasmedbio.2018.12.014
|g Vol. 45, no. 5, p. 1151 - 1163
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|t Ultrasound in medicine & biology
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856 4 _ |u https://juser.fz-juelich.de/record/862255/files/DESAINTVICTOR20191151.pdf
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