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000862342 1001_ $$0P:(DE-Juel1)169976$$aAlfonso-Prieto, Mercedes$$b0
000862342 245__ $$aMultiscale simulations on human Frizzled and Taste2 GPCRs
000862342 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2019
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000862342 520__ $$aRecently, molecular dynamics simulations, from all atom and coarse grained to hybrid methods bridging the two scales, have provided exciting functional insights into class F (Frizzled and Taste2) GPCRs (about 40 members in humans). Findings include: (i) The activation of one member of the Frizzled receptors (FZD4) involves a bending of transmembrane helix TM7 far larger than that in class A GPCRs. (ii) The affinity of an anticancer drug targeting another member (Smoothened receptor) decreases in a specific drug-resistant variant, because the mutation ultimately disrupts the binding cavity and affects TM6. (iii) A novel two-state recognition mechanism explains the very large agonist diversity for at least one member of the Taste2 GPCRs, hTAS2R46.
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000862342 7001_ $$0P:(DE-Juel1)165199$$aGiorgetti, Alejandro$$b1$$ufzj
000862342 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b2$$eCorresponding author$$ufzj
000862342 773__ $$0PERI:(DE-600)2019233-2$$a10.1016/j.sbi.2019.02.009$$gVol. 55, p. 8 - 16$$p8-16$$tCurrent opinion in structural biology$$v55$$x0959-440X$$y2019
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