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| 001 | 862342 | ||
| 005 | 20240625095116.0 | ||
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| 100 | 1 | _ | |a Alfonso-Prieto, Mercedes |0 P:(DE-Juel1)169976 |b 0 |
| 245 | _ | _ | |a Multiscale simulations on human Frizzled and Taste2 GPCRs |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2019 |b Elsevier |
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| 520 | _ | _ | |a Recently, molecular dynamics simulations, from all atom and coarse grained to hybrid methods bridging the two scales, have provided exciting functional insights into class F (Frizzled and Taste2) GPCRs (about 40 members in humans). Findings include: (i) The activation of one member of the Frizzled receptors (FZD4) involves a bending of transmembrane helix TM7 far larger than that in class A GPCRs. (ii) The affinity of an anticancer drug targeting another member (Smoothened receptor) decreases in a specific drug-resistant variant, because the mutation ultimately disrupts the binding cavity and affects TM6. (iii) A novel two-state recognition mechanism explains the very large agonist diversity for at least one member of the Taste2 GPCRs, hTAS2R46. |
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| 700 | 1 | _ | |a Giorgetti, Alejandro |0 P:(DE-Juel1)165199 |b 1 |u fzj |
| 700 | 1 | _ | |a Carloni, Paolo |0 P:(DE-Juel1)145614 |b 2 |e Corresponding author |u fzj |
| 773 | _ | _ | |a 10.1016/j.sbi.2019.02.009 |g Vol. 55, p. 8 - 16 |0 PERI:(DE-600)2019233-2 |p 8-16 |t Current opinion in structural biology |v 55 |y 2019 |x 0959-440X |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/862342/files/Manuscript_Frizzled-Taste2_Carloni_ZB-FZJ.pdf |y OpenAccess |
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