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@ARTICLE{Schweitzer:862515,
      author       = {Schweitzer, Finja and Laurent, Sarah and Fink, Gereon
                      Rudolf and Barnett, Michael H. and Reddel, Stephen and
                      Hartung, Hans-Peter and Warnke, Clemens},
      title        = {{A}ge and the risks of high-efficacy disease modifying
                      drugs in multiple sclerosis},
      journal      = {Current opinion in neurology},
      volume       = {32},
      number       = {3},
      issn         = {1350-7540},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {FZJ-2019-02818},
      pages        = {305 - 312},
      year         = {2019},
      abstract     = {A variety of high-efficacy disease-modifying therapies
                      (DMTs) are available for the treatment of multiple sclerosis
                      (MS). After evaluation and approval by regulatory agencies,
                      DMTs are likely to be administered to patients whose
                      characteristics differ from those enrolled in clinical
                      trials. This may contribute to the emergence of unexpected
                      adverse events observed in the real-world setting. Higher
                      age may be a relevant factor that could change the
                      benefit–risk balance of DMTs, as it may associate with
                      lower efficiency and higher frequency of adverse events.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30985373},
      UT           = {WOS:000480723400001},
      doi          = {10.1097/WCO.0000000000000701},
      url          = {https://juser.fz-juelich.de/record/862515},
}