TY  - JOUR
AU  - Katsigiannis, Sotirios
AU  - Krischek, Boris
AU  - Barleanu, Stefanie
AU  - Grau, Stefan
AU  - Galldiks, Norbert
AU  - Timmer, Marco
AU  - Kabbasch, Christoph
AU  - Goldbrunner, Roland
AU  - Stavrinou, Pantelis
TI  - Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma
JO  - Radiation oncology
VL  - 14
IS  - 1
SN  - 1748-717X
CY  - London
PB  - BioMed Central
M1  - FZJ-2019-02831
SP  - 73
PY  - 2019
AB  - Background and purposeTo evaluate the effect of timing of radiotherapy (RT) on survival in patients with newly diagnosed primary glioblastoma (GBM) treated with the same therapeutical protocol.Materials and methodsPatients with newly diagnosed primary GBM treated with the same therapeutical scheme between 2010 and 2015 in our institution were retrospectively reviewed. The population was trichotomized based on the time interval from surgery till initiation of RT (< 28 days, 28–33 days, > 33 days). Kaplan-Meier and Cox regression analyses were used to compare progression free survival (PFS) and overall survival (OS) between the groups. The influence of various extensively studied prognostic factors on survival was assessed by multivariate analysis.ResultsOne-hundred-fifty-one patients met the inclusion criteria. Between the three groups no significant difference in PFS (p = 0.516) or OS (p = 0.902) could be demonstrated. Residual tumor volume (RTV) and midline structures involvement were identified as independent prognostic factors of PFS while age, O-6-Methylguanine Methyltransferase (MGMT) status, Ki67 index, RTV and midline structures involvement represented independent predictors of OS. Patients starting RT after a prolonged delay (> 48 days) exhibited a significantly shorter OS (p = 0.034).
LB  - PUB:(DE-HGF)16
C6  - pmid:31036031
UR  - <Go to ISI:>//WOS:000466926300003
DO  - DOI:10.1186/s13014-019-1272-6
UR  - https://juser.fz-juelich.de/record/862532
ER  -