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@ARTICLE{Katsigiannis:862532,
      author       = {Katsigiannis, Sotirios and Krischek, Boris and Barleanu,
                      Stefanie and Grau, Stefan and Galldiks, Norbert and Timmer,
                      Marco and Kabbasch, Christoph and Goldbrunner, Roland and
                      Stavrinou, Pantelis},
      title        = {{I}mpact of time to initiation of radiotherapy on survival
                      after resection of newly diagnosed glioblastoma},
      journal      = {Radiation oncology},
      volume       = {14},
      number       = {1},
      issn         = {1748-717X},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2019-02831},
      pages        = {73},
      year         = {2019},
      abstract     = {Background and purposeTo evaluate the effect of timing of
                      radiotherapy (RT) on survival in patients with newly
                      diagnosed primary glioblastoma (GBM) treated with the same
                      therapeutical protocol.Materials and methodsPatients with
                      newly diagnosed primary GBM treated with the same
                      therapeutical scheme between 2010 and 2015 in our
                      institution were retrospectively reviewed. The population
                      was trichotomized based on the time interval from surgery
                      till initiation of RT (< 28 days, 28–33 days,
                      > 33 days). Kaplan-Meier and Cox regression analyses
                      were used to compare progression free survival (PFS) and
                      overall survival (OS) between the groups. The influence of
                      various extensively studied prognostic factors on survival
                      was assessed by multivariate
                      analysis.ResultsOne-hundred-fifty-one patients met the
                      inclusion criteria. Between the three groups no significant
                      difference in PFS (p = 0.516) or OS (p = 0.902)
                      could be demonstrated. Residual tumor volume (RTV) and
                      midline structures involvement were identified as
                      independent prognostic factors of PFS while age,
                      O-6-Methylguanine Methyltransferase (MGMT) status, Ki67
                      index, RTV and midline structures involvement represented
                      independent predictors of OS. Patients starting RT after a
                      prolonged delay (> 48 days) exhibited a significantly
                      shorter OS (p = 0.034).},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31036031},
      UT           = {WOS:000466926300003},
      doi          = {10.1186/s13014-019-1272-6},
      url          = {https://juser.fz-juelich.de/record/862532},
}