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@ARTICLE{Horos:862554,
      author       = {Horos, Rastislav and Büscher, Magdalena and Kleinendorst,
                      Rozemarijn and Alleaume, Anne-Marie and Tarafder, Abul K.
                      and Schwarzl, Thomas and Dziuba, Dmytro and Tischer,
                      Christian and Zielonka, Elisabeth M. and Adak, Asli and
                      Castello, Alfredo and Huber, Wolfgang and Sachse, Carsten
                      and Hentze, Matthias W.},
      title        = {{T}he {S}mall {N}on-coding {V}ault {RNA}1-1 {A}cts as a
                      {R}iboregulator of {A}utophagy},
      journal      = {Cell},
      volume       = {176},
      number       = {5},
      issn         = {0092-8674},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {FZJ-2019-02848},
      pages        = {1054 - 1067.e12},
      year         = {2019},
      abstract     = {Vault RNAs (vtRNA) are small non-coding RNAs transcribed by
                      RNA polymerase III found in many eukaryotes. Although they
                      have been linked to drug resistance, apoptosis, and viral
                      replication, their molecular functions remain unclear. Here,
                      we show that vault RNAs directly bind the autophagy receptor
                      sequestosome-1/p62 in human and murine cells. Overexpression
                      of human vtRNA1-1 inhibits, while its antisense LNA-mediated
                      knockdown enhances p62-dependent autophagy. Starvation of
                      cells reduces the steady-state and p62-bound levels of vault
                      RNA1-1 and induces autophagy. Mechanistically, p62 mutants
                      that fail to bind vtRNAs display increased p62
                      homo-oligomerization and augmented interaction with
                      autophagic effectors. Thus, vtRNA1-1 directly regulates
                      selective autophagy by binding p62 and interference with
                      oligomerization, a critical step of p62 function. Our data
                      uncover a striking example of the potential of RNA to
                      control protein functions directly, as previously recognized
                      for protein-protein interactions and post-translational
                      modifications.},
      cin          = {ER-C-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ER-C-3-20170113},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30773316},
      UT           = {WOS:000459257500010},
      doi          = {10.1016/j.cell.2019.01.030},
      url          = {https://juser.fz-juelich.de/record/862554},
}