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000862628 1001_ $$00000-0002-5164-8873$$aNeuner, I.$$b0
000862628 245__ $$aSimultaneous PET-MR-EEG: Technology, Challenges and Application in Clinical Neuroscience
000862628 260__ $$aNew York, NY$$bIEEE$$c2019
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000862628 520__ $$aDue to technological developments in positron emission tomography (PET) detectors and PET-MR integration, the simultaneous measurement of PET-MR-EEG has become feasible, offering the possibility of exploring the complementary information provided by each modality. Studies have already shown the benefits of simultaneous measurement using PET-MR, however, such achievements come with different technical and practical challenges. In this context, we aim to give an overview of the technical challenges involved in integrating electroencephalography with hybrid PET-MR scanners and demonstrate possible solutions. When acquiring simultaneous data from multiple modalities, the data acquisition protocol should be optimized in order to utilize time and complementary information most effectively. Thus, practical considerations with regard to protocol optimization are also discussed, alongside relevant examples. In addition to simultaneous data acquisition, another major challenge is the integration of the multimodal data, which is also addressed. Finally, a clinical application with a strong focus on neuro-psychiatry is shown. This clinical application is discussed with relevant examples from an ongoing clinical study. Finally, the possibility of utilizing the PET-MR-EEG data in search for new biomarkers for individualized medicine in clinical neuroscience is briefly explored.
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000862628 7001_ $$0P:(DE-Juel1)164396$$aRajkumar, R.$$b1
000862628 7001_ $$0P:(DE-HGF)0$$aBrambilla, C. Regio$$b2
000862628 7001_ $$0P:(DE-Juel1)169201$$aRamkiran, S.$$b3
000862628 7001_ $$00000-0002-0524-347X$$aRuch, A.$$b4
000862628 7001_ $$0P:(DE-Juel1)172782$$aOrth, L.$$b5
000862628 7001_ $$0P:(DE-Juel1)138244$$aFarrher, E.$$b6
000862628 7001_ $$0P:(DE-Juel1)144215$$aMauler, J.$$b7
000862628 7001_ $$0P:(DE-Juel1)156350$$aWyss, C.$$b8
000862628 7001_ $$0P:(DE-Juel1)131788$$aKops, E. Rota$$b9
000862628 7001_ $$0P:(DE-Juel1)131791$$aScheins, J.$$b10
000862628 7001_ $$0P:(DE-Juel1)131797$$aTellmann, L.$$b11
000862628 7001_ $$0P:(DE-Juel1)131831$$aLang, M.$$b12
000862628 7001_ $$0P:(DE-Juel1)131818$$aErmert, J.$$b13
000862628 7001_ $$0P:(DE-Juel1)131757$$aDammers, J.$$b14
000862628 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, B.$$b15
000862628 7001_ $$0P:(DE-Juel1)164254$$aLerche, C.$$b16
000862628 7001_ $$00000-0001-5105-1922$$aHeekeren, K.$$b17
000862628 7001_ $$0P:(DE-HGF)0$$aKawohl, W.$$b18
000862628 7001_ $$0P:(DE-Juel1)131777$$aLangen, K.-J.$$b19
000862628 7001_ $$00000-0002-6751-7165$$aHerzog, H.$$b20
000862628 7001_ $$0P:(DE-Juel1)131794$$aShah, N. J.$$b21$$eCorresponding author
000862628 773__ $$0PERI:(DE-600)2867672-5$$a10.1109/TRPMS.2018.2886525$$gVol. 3, no. 3, p. 377 - 385$$n3$$p377 - 385$$tIEEE transactions on radiation and plasma medical sciences$$v3$$x2469-7303$$y2019
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