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@ARTICLE{Papagiannopoulos:862694,
      author       = {Papagiannopoulos, Aristeidis and Vlassi, Eleni and
                      Radulescu, Aurel},
      title        = {{R}eorganizations inside thermally stabilized
                      protein/polysaccharide nanocarriers investigated by small
                      angle neutron scattering},
      journal      = {Carbohydrate polymers},
      volume       = {218},
      issn         = {0144-8617},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2019-02948},
      pages        = {218 - 225},
      year         = {2019},
      abstract     = {We use small angle neutron scattering (SANS) to
                      characterize the internal morphology of nanoparticles (NPs)
                      formed by the complexation between chondroitin sulfate (CS)
                      and bovine serum albumin (BSA) and subsequent stabilization
                      by thermal treatment. We demonstrate that SANS can quantify
                      the internal rearrangements and protein morphology
                      alterations upon thermal treatment and solution conditions
                      variations. A three-level Guinier/power-law hierarchical
                      model identifies BSA globules, interconnected clusters of
                      globules and higher aggregates. The effect of temperature
                      treatment which causes protein denaturation and β-sheet
                      inter-globular associations is captured by the model at the
                      relevant length scales 1–100 nm. Furthermore, the
                      nanogel behavior of the thermally treated CS/BSA NPs, which
                      up to this moment had been characterized by light
                      scattering, is elucidated. Loading of the nutraceutical
                      compound β-carotene (β-C) is revealed to occur at the
                      outer regions of the NPs. This study demonstrates that the
                      combination of SANS and a hierarchical model for data
                      analysis may provide very useful insights for nanocarriers
                      which are based on polysaccharide/protein complexes and aim
                      at biomedical applications and the food industry.},
      cin          = {JCNS-FRM-II / Neutronenstreuung ; JCNS-1 / MLZ},
      ddc          = {660},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31221324},
      UT           = {WOS:000471864400025},
      doi          = {10.1016/j.carbpol.2019.04.077},
      url          = {https://juser.fz-juelich.de/record/862694},
}