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@ARTICLE{Papagiannopoulos:862694,
author = {Papagiannopoulos, Aristeidis and Vlassi, Eleni and
Radulescu, Aurel},
title = {{R}eorganizations inside thermally stabilized
protein/polysaccharide nanocarriers investigated by small
angle neutron scattering},
journal = {Carbohydrate polymers},
volume = {218},
issn = {0144-8617},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {FZJ-2019-02948},
pages = {218 - 225},
year = {2019},
abstract = {We use small angle neutron scattering (SANS) to
characterize the internal morphology of nanoparticles (NPs)
formed by the complexation between chondroitin sulfate (CS)
and bovine serum albumin (BSA) and subsequent stabilization
by thermal treatment. We demonstrate that SANS can quantify
the internal rearrangements and protein morphology
alterations upon thermal treatment and solution conditions
variations. A three-level Guinier/power-law hierarchical
model identifies BSA globules, interconnected clusters of
globules and higher aggregates. The effect of temperature
treatment which causes protein denaturation and β-sheet
inter-globular associations is captured by the model at the
relevant length scales 1–100 nm. Furthermore, the
nanogel behavior of the thermally treated CS/BSA NPs, which
up to this moment had been characterized by light
scattering, is elucidated. Loading of the nutraceutical
compound β-carotene (β-C) is revealed to occur at the
outer regions of the NPs. This study demonstrates that the
combination of SANS and a hierarchical model for data
analysis may provide very useful insights for nanocarriers
which are based on polysaccharide/protein complexes and aim
at biomedical applications and the food industry.},
cin = {JCNS-FRM-II / Neutronenstreuung ; JCNS-1 / MLZ},
ddc = {660},
cid = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3},
pnm = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
/ 6G15 - FRM II / MLZ (POF3-6G15)},
pid = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
experiment = {EXP:(DE-MLZ)KWS2-20140101},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:31221324},
UT = {WOS:000471864400025},
doi = {10.1016/j.carbpol.2019.04.077},
url = {https://juser.fz-juelich.de/record/862694},
}