%0 Journal Article
%A Horos, Rastislav
%A Büscher, Magdalena
%A Sachse, Carsten
%A Hentze, Matthias W.
%T Vault RNA emerges as a regulator of selective autophagy
%J Autophagy
%V 15
%N 8
%@ 1554-8635
%C Abingdon, Oxon
%I Taylor & Francis
%M FZJ-2019-02993
%P  1463-1464
%D 2019
%X The selective autophagic receptor SQSTM1/p62 ushers cargo to phagophores, the precursors of autophagosomes, and serves as a platform for autophagy initiation. We discovered that SQSTM1 is an RNA-binding protein that interacts with vault RNAs. Vault RNAs are small non-coding RNAs found in many eukaryotes and transcribed by POLR3 (RNA polymerase III). The levels of VTRNA1–1 (vault RNA 1-1) regulate SQSTM1-mediated autophagy and ubiquitin aggregate clearance. Vault RNA interferes with oligomerization of SQSTM1, which is in turn critical for its autophagic function. Our study uncovered a novel mode of regulation of a protein’s activity by RNA, termed riboregulation.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31006338
%U <Go to ISI:>//WOS:000469723400001
%R 10.1080/15548627.2019.1609861
%U https://juser.fz-juelich.de/record/862751