000862751 001__ 862751
000862751 005__ 20210130001608.0
000862751 0247_ $$2doi$$a10.1080/15548627.2019.1609861
000862751 0247_ $$2ISSN$$a1554-8627
000862751 0247_ $$2ISSN$$a1554-8635
000862751 0247_ $$2altmetric$$aaltmetric:59393590
000862751 0247_ $$2pmid$$apmid:31006338
000862751 0247_ $$2WOS$$aWOS:000469723400001
000862751 037__ $$aFZJ-2019-02993
000862751 041__ $$aEnglish
000862751 082__ $$a570
000862751 1001_ $$0P:(DE-HGF)0$$aHoros, Rastislav$$b0$$eCorresponding author
000862751 245__ $$aVault RNA emerges as a regulator of selective autophagy
000862751 260__ $$aAbingdon, Oxon$$bTaylor & Francis$$c2019
000862751 3367_ $$2DRIVER$$aarticle
000862751 3367_ $$2DataCite$$aOutput Types/Journal article
000862751 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1563199843_12605
000862751 3367_ $$2BibTeX$$aARTICLE
000862751 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000862751 3367_ $$00$$2EndNote$$aJournal Article
000862751 520__ $$aThe selective autophagic receptor SQSTM1/p62 ushers cargo to phagophores, the precursors of autophagosomes, and serves as a platform for autophagy initiation. We discovered that SQSTM1 is an RNA-binding protein that interacts with vault RNAs. Vault RNAs are small non-coding RNAs found in many eukaryotes and transcribed by POLR3 (RNA polymerase III). The levels of VTRNA1–1 (vault RNA 1-1) regulate SQSTM1-mediated autophagy and ubiquitin aggregate clearance. Vault RNA interferes with oligomerization of SQSTM1, which is in turn critical for its autophagic function. Our study uncovered a novel mode of regulation of a protein’s activity by RNA, termed riboregulation.
000862751 536__ $$0G:(DE-HGF)POF3-551$$a551 - Functional Macromolecules and Complexes (POF3-551)$$cPOF3-551$$fPOF III$$x0
000862751 588__ $$aDataset connected to CrossRef
000862751 7001_ $$00000-0002-2215-3329$$aBüscher, Magdalena$$b1
000862751 7001_ $$0P:(DE-Juel1)173949$$aSachse, Carsten$$b2
000862751 7001_ $$00000-0002-4023-7876$$aHentze, Matthias W.$$b3
000862751 773__ $$0PERI:(DE-600)2262043-6$$a10.1080/15548627.2019.1609861$$gp. 1 - 2$$n8$$p 1463-1464$$tAutophagy$$v15$$x1554-8635$$y2019
000862751 8564_ $$uhttps://juser.fz-juelich.de/record/862751/files/Vault%20RNA%20emerges%20as%20a%20regulator%20of%20selective%20autophagy.pdf$$yRestricted
000862751 8564_ $$uhttps://juser.fz-juelich.de/record/862751/files/Vault%20RNA%20emerges%20as%20a%20regulator%20of%20selective%20autophagy.pdf?subformat=pdfa$$xpdfa$$yRestricted
000862751 909CO $$ooai:juser.fz-juelich.de:862751$$pVDB
000862751 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)173949$$aForschungszentrum Jülich$$b2$$kFZJ
000862751 9131_ $$0G:(DE-HGF)POF3-551$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vFunctional Macromolecules and Complexes$$x0
000862751 9141_ $$y2019
000862751 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000862751 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000862751 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000862751 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bAUTOPHAGY : 2017
000862751 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000862751 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000862751 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000862751 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000862751 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000862751 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bAUTOPHAGY : 2017
000862751 920__ $$lyes
000862751 9201_ $$0I:(DE-Juel1)ER-C-3-20170113$$kER-C-3$$lStrukturbiologie$$x0
000862751 980__ $$ajournal
000862751 980__ $$aVDB
000862751 980__ $$aI:(DE-Juel1)ER-C-3-20170113
000862751 980__ $$aUNRESTRICTED