TY  - JOUR
AU  - Horos, Rastislav
AU  - Büscher, Magdalena
AU  - Sachse, Carsten
AU  - Hentze, Matthias W.
TI  - Vault RNA emerges as a regulator of selective autophagy
JO  - Autophagy
VL  - 15
IS  - 8
SN  - 1554-8635
CY  - Abingdon, Oxon
PB  - Taylor & Francis
M1  - FZJ-2019-02993
SP  -  1463-1464
PY  - 2019
AB  - The selective autophagic receptor SQSTM1/p62 ushers cargo to phagophores, the precursors of autophagosomes, and serves as a platform for autophagy initiation. We discovered that SQSTM1 is an RNA-binding protein that interacts with vault RNAs. Vault RNAs are small non-coding RNAs found in many eukaryotes and transcribed by POLR3 (RNA polymerase III). The levels of VTRNA1–1 (vault RNA 1-1) regulate SQSTM1-mediated autophagy and ubiquitin aggregate clearance. Vault RNA interferes with oligomerization of SQSTM1, which is in turn critical for its autophagic function. Our study uncovered a novel mode of regulation of a protein’s activity by RNA, termed riboregulation.
LB  - PUB:(DE-HGF)16
C6  - pmid:31006338
UR  - <Go to ISI:>//WOS:000469723400001
DO  - DOI:10.1080/15548627.2019.1609861
UR  - https://juser.fz-juelich.de/record/862751
ER  -