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@ARTICLE{Horos:862751,
      author       = {Horos, Rastislav and Büscher, Magdalena and Sachse,
                      Carsten and Hentze, Matthias W.},
      title        = {{V}ault {RNA} emerges as a regulator of selective
                      autophagy},
      journal      = {Autophagy},
      volume       = {15},
      number       = {8},
      issn         = {1554-8635},
      address      = {Abingdon, Oxon},
      publisher    = {Taylor $\&$ Francis},
      reportid     = {FZJ-2019-02993},
      pages        = {1463-1464},
      year         = {2019},
      abstract     = {The selective autophagic receptor SQSTM1/p62 ushers cargo
                      to phagophores, the precursors of autophagosomes, and serves
                      as a platform for autophagy initiation. We discovered that
                      SQSTM1 is an RNA-binding protein that interacts with vault
                      RNAs. Vault RNAs are small non-coding RNAs found in many
                      eukaryotes and transcribed by POLR3 (RNA polymerase III).
                      The levels of VTRNA1–1 (vault RNA 1-1) regulate
                      SQSTM1-mediated autophagy and ubiquitin aggregate clearance.
                      Vault RNA interferes with oligomerization of SQSTM1, which
                      is in turn critical for its autophagic function. Our study
                      uncovered a novel mode of regulation of a protein’s
                      activity by RNA, termed riboregulation.},
      cin          = {ER-C-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ER-C-3-20170113},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31006338},
      UT           = {WOS:000469723400001},
      doi          = {10.1080/15548627.2019.1609861},
      url          = {https://juser.fz-juelich.de/record/862751},
}