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001     862751
005     20210130001608.0
024 7 _ |a 10.1080/15548627.2019.1609861
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100 1 _ |a Horos, Rastislav
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245 _ _ |a Vault RNA emerges as a regulator of selective autophagy
260 _ _ |a Abingdon, Oxon
|c 2019
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520 _ _ |a The selective autophagic receptor SQSTM1/p62 ushers cargo to phagophores, the precursors of autophagosomes, and serves as a platform for autophagy initiation. We discovered that SQSTM1 is an RNA-binding protein that interacts with vault RNAs. Vault RNAs are small non-coding RNAs found in many eukaryotes and transcribed by POLR3 (RNA polymerase III). The levels of VTRNA1–1 (vault RNA 1-1) regulate SQSTM1-mediated autophagy and ubiquitin aggregate clearance. Vault RNA interferes with oligomerization of SQSTM1, which is in turn critical for its autophagic function. Our study uncovered a novel mode of regulation of a protein’s activity by RNA, termed riboregulation.
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700 1 _ |a Büscher, Magdalena
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700 1 _ |a Sachse, Carsten
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700 1 _ |a Hentze, Matthias W.
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773 _ _ |a 10.1080/15548627.2019.1609861
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