000862855 001__ 862855
000862855 005__ 20210130001657.0
000862855 0247_ $$2doi$$a10.1016/j.parkreldis.2019.05.015
000862855 0247_ $$2ISSN$$a1353-8020
000862855 0247_ $$2ISSN$$a1873-5126
000862855 0247_ $$2altmetric$$aaltmetric:60426010
000862855 0247_ $$2pmid$$apmid:31105014
000862855 0247_ $$2WOS$$aWOS:000491682900010
000862855 037__ $$aFZJ-2019-03054
000862855 082__ $$a610
000862855 1001_ $$00000-0003-0311-3839$$aTrampenau, Leif$$b0$$eCorresponding author
000862855 245__ $$aParkinsonian patients do not utilize probabilistic advance information in a grip-lift task
000862855 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2019
000862855 3367_ $$2DRIVER$$aarticle
000862855 3367_ $$2DataCite$$aOutput Types/Journal article
000862855 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1570001525_16323
000862855 3367_ $$2BibTeX$$aARTICLE
000862855 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000862855 3367_ $$00$$2EndNote$$aJournal Article
000862855 520__ $$aIntroductionPatients with Parkinson's disease (PD) are known to have decision-making impairments in tasks involving probabilistic information. How PD patients utilize task-relevant probabilistic advance information to plan and initiate common motor tasks like grasping has not yet been studied.MethodsPD patients (n = 15, OFF medication) and control participants repeatedly grasped and lifted an object, the weight of which could be light, medium, or heavy. Visual cues provided explicit probabilistic information about the upcoming weight at the start of each grip-lift trial. This information allows the force of the grasping fingers to be scaled predictively so that it matches the likely weight, with a suitable rate of initial force increase. Deterministic cues announced the upcoming weight with certainty in other grip-lift trials. In a weight adjustment experiment, participants associated each probabilistic cue with a specific heaviness.ResultsThe weight adjustment experiments showed that the probabilistic cues were understood correctly. However, PD patients utilized the probabilistic information significantly less than controls during the grip-lift task. Specifically, patients did not initiate their grasp more forcefully when probabilistic cues announced a high likelihood (66.7% probability) of a heavy weight, in contrast to controls. Thus, probabilistic cues that encouraged a more vigorous action had no effect in PD. Nevertheless, patients and controls scaled their forces appropriately when deterministic cues announced the forthcoming weights unambiguously.ConclusionsPD patients do not invest a high movement effort to initiate a grip-lift unless the necessity of such a vigorous action initiation is decidedly clear.
000862855 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000862855 588__ $$aDataset connected to CrossRef
000862855 7001_ $$0P:(DE-HGF)0$$aKuhtz-Buschbeck, Johann P.$$b1
000862855 7001_ $$0P:(DE-Juel1)169110$$avan Eimeren, Thilo$$b2$$ufzj
000862855 773__ $$0PERI:(DE-600)2027635-7$$a10.1016/j.parkreldis.2019.05.015$$gp. S1353802019302366$$p67-72$$tParkinsonism & related disorders$$v65$$x1353-8020$$y2019
000862855 909CO $$ooai:juser.fz-juelich.de:862855$$pVDB
000862855 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)169110$$aForschungszentrum Jülich$$b2$$kFZJ
000862855 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000862855 9141_ $$y2019
000862855 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000862855 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000862855 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPARKINSONISM RELAT D : 2017
000862855 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000862855 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000862855 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000862855 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000862855 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000862855 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000862855 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000862855 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000862855 920__ $$lyes
000862855 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000862855 980__ $$ajournal
000862855 980__ $$aVDB
000862855 980__ $$aI:(DE-Juel1)INM-3-20090406
000862855 980__ $$aUNRESTRICTED