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@ARTICLE{Trampenau:862855,
      author       = {Trampenau, Leif and Kuhtz-Buschbeck, Johann P. and van
                      Eimeren, Thilo},
      title        = {{P}arkinsonian patients do not utilize probabilistic
                      advance information in a grip-lift task},
      journal      = {Parkinsonism $\&$ related disorders},
      volume       = {65},
      issn         = {1353-8020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2019-03054},
      pages        = {67-72},
      year         = {2019},
      abstract     = {IntroductionPatients with Parkinson's disease (PD) are
                      known to have decision-making impairments in tasks involving
                      probabilistic information. How PD patients utilize
                      task-relevant probabilistic advance information to plan and
                      initiate common motor tasks like grasping has not yet been
                      studied.MethodsPD patients (n = 15, OFF medication) and
                      control participants repeatedly grasped and lifted an
                      object, the weight of which could be light, medium, or
                      heavy. Visual cues provided explicit probabilistic
                      information about the upcoming weight at the start of each
                      grip-lift trial. This information allows the force of the
                      grasping fingers to be scaled predictively so that it
                      matches the likely weight, with a suitable rate of initial
                      force increase. Deterministic cues announced the upcoming
                      weight with certainty in other grip-lift trials. In a weight
                      adjustment experiment, participants associated each
                      probabilistic cue with a specific heaviness.ResultsThe
                      weight adjustment experiments showed that the probabilistic
                      cues were understood correctly. However, PD patients
                      utilized the probabilistic information significantly less
                      than controls during the grip-lift task. Specifically,
                      patients did not initiate their grasp more forcefully when
                      probabilistic cues announced a high likelihood $(66.7\%$
                      probability) of a heavy weight, in contrast to controls.
                      Thus, probabilistic cues that encouraged a more vigorous
                      action had no effect in PD. Nevertheless, patients and
                      controls scaled their forces appropriately when
                      deterministic cues announced the forthcoming weights
                      unambiguously.ConclusionsPD patients do not invest a high
                      movement effort to initiate a grip-lift unless the necessity
                      of such a vigorous action initiation is decidedly clear.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31105014},
      UT           = {WOS:000491682900010},
      doi          = {10.1016/j.parkreldis.2019.05.015},
      url          = {https://juser.fz-juelich.de/record/862855},
}