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@ARTICLE{Shymanskaya:863073,
      author       = {Shymanskaya, Aliaksandra and Worthoff, Wieland A. and
                      Stoffels, Gabriele and Lindemeyer, Johannes and Neumaier,
                      Bernd and Lohmann, Philipp and Galldiks, Norbert and Langen,
                      Karl-Josef and Shah, N. J.},
      title        = {{C}omparison of [18{F}]{F}luoroethyltyrosine {PET} and
                      {S}odium {MRI} in {C}erebral {G}liomas: a {P}ilot {S}tudy},
      journal      = {Molecular imaging $\&$ biology},
      volume       = {22},
      number       = {-},
      issn         = {1860-2002},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science84323},
      reportid     = {FZJ-2019-03190},
      pages        = {198–207},
      year         = {2020},
      abstract     = {PurposePositron emission tomography (PET) using
                      O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) improves the
                      diagnostics of cerebral gliomas compared with conventional
                      magnetic resonance imaging (MRI). Sodium MRI is an evolving
                      method to assess tumor metabolism. In this pilot study, we
                      explored the relationship of [18F]FET-PET and sodium MRI in
                      patients with cerebral gliomas in relation to the mutational
                      status of the enzyme isocitrate dehydrogenase
                      (IDH).ProceduresTen patients with untreated cerebral gliomas
                      and one patient with a recurrent glioblastoma (GBM) were
                      investigated by dynamic [18F]FET-PET and sodium MRI using an
                      enhanced simultaneous single-quantum- and
                      triple-quantum-filtered imaging of 23Na (SISTINA) sequence
                      to estimate total (NaT), weighted non-restricted (NaNR,
                      mainly extracellular), and restricted (NaR, mainly
                      intracellular) sodium in tumors and normal brain tissue.
                      [18F]FET uptake and sodium parameters in tumors with a
                      different IDH mutational status were compared. After biopsy
                      or resection, histology and the IDH mutational status were
                      determined neuropathologically.ResultsNaT (p = 0.05),
                      tumor-to-brain ratios (TBR) of NaT (p = 0.02), NaNR
                      (p = 0.003), and the ratio of NaT/NaR (p < 0.001)
                      were significantly higher in IDH-mutated than in
                      IDH-wild-type gliomas (n = 5 patients each) while NaR
                      was significantly lower in IDH-mutated gliomas
                      (p = 0.01). [18F]FET parameters (TBR, time-to-peak) were
                      not predictive of IDH status in this small cohort of
                      patients. There was no obvious relationship between sodium
                      distribution and [18F]FET uptake. The patient with a
                      recurrent GBM exhibited an additional radiation injury with
                      strong abnormalities in sodium MRI.ConclusionsSodium MRI
                      appears to be more strongly related to the IDH mutational
                      status than are [18F]FET-PET parameters. A further
                      evaluation of the combination of the two methods in a larger
                      group of high- and low-grade gliomas seems promising.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN / INM-5},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      $I:(DE-82)080010_20140620$ / I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30989437},
      UT           = {WOS:000513265700026},
      doi          = {10.1007/s11307-019-01349-y},
      url          = {https://juser.fz-juelich.de/record/863073},
}