TY  - JOUR
AU  - Einevoll, Gaute T.
AU  - Destexhe, Alain
AU  - Diesmann, Markus
AU  - Grün, Sonja
AU  - Jirsa, Viktor
AU  - de Kamps, Marc
AU  - Migliore, Michele
AU  - Ness, Torbjørn V.
AU  - Plesser, Hans E.
AU  - Schürmann, Felix
TI  - The Scientific Case for Brain Simulations
JO  - Neuron
VL  - 102
IS  - 4
SN  - 0896-6273
CY  - New York, NY
PB  - Elsevier
M1  - FZJ-2019-03198
SP  - 735 - 744
PY  - 2019
AB  - A key element of the European Union’s Human Brain Project (HBP) and other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scales between the neuron and system levels in the brain, and why a set of brain simulators based on neuron models at different levels of biological detail should therefore be developed. To allow for systematic refinement of candidate network models by comparison with experiments, the simulations should be multimodal in the sense that they should predict not only action potentials, but also electric, magnetic, and optical signals measured at the population and system levels.
LB  - PUB:(DE-HGF)16
C6  - pmid:31121126
UR  - <Go to ISI:>//WOS:000468597000011
DO  - DOI:10.1016/j.neuron.2019.03.027
UR  - https://juser.fz-juelich.de/record/863081
ER  -