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| 001 | 863081 | ||
| 005 | 20240313103124.0 | ||
| 024 | 7 | _ | |a 10.1016/j.neuron.2019.03.027 |2 doi |
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| 100 | 1 | _ | |a Einevoll, Gaute T. |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a The Scientific Case for Brain Simulations |
| 260 | _ | _ | |a New York, NY |c 2019 |b Elsevier |
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| 520 | _ | _ | |a A key element of the European Union’s Human Brain Project (HBP) and other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scales between the neuron and system levels in the brain, and why a set of brain simulators based on neuron models at different levels of biological detail should therefore be developed. To allow for systematic refinement of candidate network models by comparison with experiments, the simulations should be multimodal in the sense that they should predict not only action potentials, but also electric, magnetic, and optical signals measured at the population and system levels. |
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| 536 | _ | _ | |a HBP - The Human Brain Project (604102) |0 G:(EU-Grant)604102 |c 604102 |f FP7-ICT-2013-FET-F |x 2 |
| 536 | _ | _ | |a HBP SGA1 - Human Brain Project Specific Grant Agreement 1 (720270) |0 G:(EU-Grant)720270 |c 720270 |f H2020-Adhoc-2014-20 |x 3 |
| 536 | _ | _ | |a HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) |0 G:(EU-Grant)785907 |c 785907 |f H2020-SGA-FETFLAG-HBP-2017 |x 4 |
| 536 | _ | _ | |a DEEP-EST - DEEP - Extreme Scale Technologies (754304) |0 G:(EU-Grant)754304 |c 754304 |f H2020-FETHPC-2016 |x 5 |
| 536 | _ | _ | |a DFG project 322093511 - Kognitive Leistung als Ergebnis koordinierter neuronaler Aktivität in unreifen präfrontal-hippokampalen Netzwerken (322093511) |0 G:(GEPRIS)322093511 |c 322093511 |x 6 |
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| 536 | _ | _ | |a GRK 2416 - GRK 2416: MultiSenses-MultiScales: Neue Ansätze zur Aufklärung neuronaler multisensorischer Integration (368482240) |0 G:(GEPRIS)368482240 |c 368482240 |x 10 |
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| 700 | 1 | _ | |a Destexhe, Alain |0 P:(DE-HGF)0 |b 1 |
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| 700 | 1 | _ | |a Jirsa, Viktor |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a de Kamps, Marc |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Migliore, Michele |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Ness, Torbjørn V. |0 P:(DE-HGF)0 |b 7 |
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| 773 | _ | _ | |a 10.1016/j.neuron.2019.03.027 |g Vol. 102, no. 4, p. 735 - 744 |0 PERI:(DE-600)2001944-0 |n 4 |p 735 - 744 |t Neuron |v 102 |y 2019 |x 0896-6273 |
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