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@ARTICLE{Schall:863088,
      author       = {Schall, Melissa and Iordanishvili, Elene and Mauler, Jörg
                      and Oros‐Peusquens, Ana‐Maria and Shah, N. J.},
      title        = {{I}ncreasing body mass index in an elderly cohort:
                      {E}ffects on the quantitative {MR} parameters of the brain},
      journal      = {Journal of magnetic resonance imaging},
      volume       = {51},
      number       = {2},
      issn         = {1522-2586},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2019-03202},
      pages        = {514-523},
      year         = {2020},
      abstract     = {BackgroundBody mass index (BMI) is increasing in a large
                      number of elderly persons. This increase in BMI is known to
                      put one at risk for many "diseases of aging," although less
                      is known about how a change in BMI may affect the brains of
                      the elderly.PurposeTo investigate the relationship between
                      BMI and quantitative water content, T1, T2*, and the
                      semi‐quantitative magnetization transfer ratio (MTR) of
                      various structures in elderly brains.Study
                      TypeCross‐sectional.SubjectsForty‐two adults (BMI range:
                      19.1–33.5 kg/m2, age range: 58–80 years).Field
                      Strength3T MRI (two multi‐echo gradient echoes, actual
                      flip angle imaging, magnetization prepared rapid gradient
                      echo, fluid attenuated inversion recovery).AssessmentThe 3D
                      two‐point method was used to derive (semi‐)quantitative
                      parameters in global white (WM) and gray matter (GM) and
                      their regions as defined by the Johns Hopkins University and
                      the Montreal Neurological Institute atlases.Statistical
                      TestsMultivariate linear regression with BMI as principal
                      regressor, corrected for the additional regressors age,
                      gender, and glycated hemoglobin. Spearman correlation
                      between quantitative parameters of the regions showing
                      significant changes and the lipid spectra / C‐reactive
                      protein (CRP). Voxel‐based morphometry and analysis of
                      covariance (ANCOVA) to explore changes in the GM
                      volume.ResultsT1 increased significantly (P < 0.05) in
                      the frontal, temporal, and parietal cortices, while the
                      bilateral corona radiata, right superior longitudinal
                      fasciculus, as well as the corpus callosum showed
                      significant changes in the WM regions. T2* increased
                      significantly in the global WM and left corona radiata.
                      Changes in MTR and the free water content did not reach
                      significance. No significant correlation between any
                      quantitative parameter and the lipid spectra or CRP could be
                      identified.Data ConclusionThese results suggest that an
                      elevated BMI predominantly affects T1 in WM as well as GM
                      structures in the elderly human brain.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31150149},
      UT           = {WOS:000506450300018},
      doi          = {10.1002/jmri.26807},
      url          = {https://juser.fz-juelich.de/record/863088},
}