% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@INBOOK{Lewis:863112,
      author       = {Ermert, Johannes and Neumaier, Bernd},
      editor       = {Lewis, Jason S. and Windhorst, Albert D. and Zeglis, Brian
                      M.},
      title        = {{T}he {R}adiopharmaceutical {C}hemistry of {F}luorine-18:
                      {N}ucleophilic {F}luorinations},
      address      = {Cham},
      publisher    = {Springer International Publishing},
      reportid     = {FZJ-2019-03215},
      pages        = {273-283},
      year         = {2019},
      comment      = {Radiopharmaceutical Chemistry / Lewis, Jason S. (Editor) ,
                      Chapter 15 ; ISBN: 978-3-319-98946-4 ;
                      doi:10.1007/978-3-319-98947-1},
      booktitle     = {Radiopharmaceutical Chemistry / Lewis,
                       Jason S. (Editor) , Chapter 15 ; ISBN:
                       978-3-319-98946-4 ;
                       doi:10.1007/978-3-319-98947-1},
      abstract     = {The positron-emitting radionuclide fluorine-18 plays a
                      prominent role in radiopharmaceuticals for positron emission
                      tomography (PET) due to its favourable nuclear decay
                      properties. Depending on the production method, 18F can be
                      obtained in two different chemical forms: electrophilic
                      [18F]fluorine gas and nucleophilic [18F]fluoride.
                      Nucleophilic [18F]fluoride exhibits several advantages with
                      respect to accessibility and chemical handling. Therefore,
                      nucleophilic 18F-substitution reactions are of pivotal
                      importance for the production of PET radiotracers. This
                      chapter is devoted to this class of reactions, and in the
                      following pages, we seek to provide a general overview of
                      18F itself as well as insights into nucleophilic
                      18F-substitution reactions. More specifically, the
                      prerequisites for this reaction with regard to solvent,
                      leaving groups, reactants, etc. are examined. Furthermore,
                      several examples are discussed which demonstrate the
                      potential of this reaction to create highly clinical
                      relevant PET tracers. Finally, this chapter also provides
                      practical tips and tricks for those performing this reaction
                      in the laboratory.},
      cin          = {INM-5},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)7},
      doi          = {10.1007/978-3-319-98947-1_15},
      url          = {https://juser.fz-juelich.de/record/863112},
}