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@ARTICLE{Huber:863449,
      author       = {Huber, Catharina V and Jakobs, Barbara D and Mishra, Laxmi
                      S and Niedermaier, Stefan and Stift, Marc and Winter, Gudrun
                      and Adamska, Iwona and Funk, Christiane and Huesgen, Pitter
                      and Funck, Dietmar},
      title        = {{DEG}10 contributes to mitochondrial proteostasis, root
                      growth and seed yield in {A}rabidopsis},
      journal      = {The journal of experimental botany},
      volume       = {70},
      number       = {19},
      issn         = {1460-2431},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2019-03513},
      pages        = {5423–5436},
      year         = {2019},
      abstract     = {Maintaining mitochondrial proteome integrity is especially
                      important under stress conditions to ensure a continued ATP
                      supply for protection and adaptation responses in plants.
                      Deg/HtrA proteases are important factors in the cellular
                      protein quality control system, but little is known about
                      their function in mitochondria. Here we analyzed the
                      expression pattern and physiological function of Arabidopsis
                      thaliana DEG10, which has homologs in all photosynthetic
                      eukaryotes. Both expression of DEG10:GFP fusion proteins and
                      immunoblotting after cell fractionation showed an
                      unambiguous subcellular localization exclusively in
                      mitochondria. DEG10 promoter:GUS fusion constructs showed
                      that DEG10 is expressed in trichomes but also in the
                      vascular tissue of roots and aboveground organs. DEG10
                      loss-of-function mutants were impaired in root elongation,
                      especially at elevated temperature. Quantitative proteome
                      analysis revealed concomitant changes in the abundance of
                      mitochondrial respiratory chain components and assembly
                      factors, which partially appeared to depend on altered
                      mitochondrial retrograde signaling. Under field conditions,
                      lack of DEG10 caused a decrease in seed production. Taken
                      together, our findings demonstrate that DEG10 affects
                      mitochondrial proteostasis, is required for optimal root
                      development and seed set under challenging environmental
                      conditions, and thus contributes to stress tolerance of
                      plants.},
      cin          = {ZEA-3},
      ddc          = {580},
      cid          = {I:(DE-Juel1)ZEA-3-20090406},
      pnm          = {582 - Plant Science (POF3-582) / ProPlantStress -
                      Proteolytic processing in plant stress signal transduction
                      and responses to abiotic stress and pathogen attack
                      (639905)},
      pid          = {G:(DE-HGF)POF3-582 / G:(EU-Grant)639905},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31225599},
      UT           = {WOS:000491240900029},
      doi          = {10.1093/jxb/erz294},
      url          = {https://juser.fz-juelich.de/record/863449},
}