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000863462 1001_ $$0P:(DE-HGF)0$$aGleeson, Padraig$$b0
000863462 245__ $$aOpen Source Brain: A Collaborative Resource for Visualizing, Analyzing, Simulating, and Developing Standardized Models of Neurons and Circuits
000863462 260__ $$aNew York, NY$$bElsevier$$c2019
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000863462 520__ $$aComputational models are powerful tools for exploring the properties of complex biological systems. In neuroscience, data-driven models of neural circuits that span multiple scales are increasingly being used to understand brain function in health and disease. But their adoption and reuse has been limited by the specialist knowledge required to evaluate and use them. To address this, we have developed Open Source Brain, a platform for sharing, viewing, analyzing, and simulating standardized models from different brain regions and species. Model structure and parameters can be automatically visualized and their dynamical properties explored through browser-based simulations. Infrastructure and tools for collaborative interaction, development, and testing are also provided. We demonstrate how existing components can be reused by constructing new models of inhibition-stabilized cortical networks that match recent experimental results. These features of Open Source Brain improve the accessibility, transparency, and reproducibility of models and facilitate their reuse by the wider community.
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000863462 7001_ $$0P:(DE-HGF)0$$aCantarelli, Matteo$$b1
000863462 7001_ $$0P:(DE-HGF)0$$aMarin, Boris$$b2
000863462 7001_ $$0P:(DE-HGF)0$$aQuintana, Adrian$$b3
000863462 7001_ $$0P:(DE-HGF)0$$aEarnshaw, Matt$$b4
000863462 7001_ $$0P:(DE-HGF)0$$aSadeh, Sadra$$b5
000863462 7001_ $$0P:(DE-HGF)0$$aPiasini, Eugenio$$b6
000863462 7001_ $$0P:(DE-HGF)0$$aBirgiolas, Justas$$b7
000863462 7001_ $$0P:(DE-HGF)0$$aCannon, Robert C.$$b8
000863462 7001_ $$0P:(DE-HGF)0$$aCayco-Gajic, N. Alex$$b9
000863462 7001_ $$0P:(DE-HGF)0$$aCrook, Sharon$$b10
000863462 7001_ $$0P:(DE-Juel1)171568$$aDavison, Andrew P.$$b11
000863462 7001_ $$0P:(DE-HGF)0$$aDura-Bernal, Salvador$$b12
000863462 7001_ $$0P:(DE-HGF)0$$aEcker, András$$b13
000863462 7001_ $$0P:(DE-HGF)0$$aHines, Michael L.$$b14
000863462 7001_ $$0P:(DE-HGF)0$$aIdili, Giovanni$$b15
000863462 7001_ $$0P:(DE-HGF)0$$aLanore, Frederic$$b16
000863462 7001_ $$0P:(DE-HGF)0$$aLarson, Stephen D.$$b17
000863462 7001_ $$0P:(DE-HGF)0$$aLytton, William W.$$b18
000863462 7001_ $$0P:(DE-HGF)0$$aMajumdar, Amitava$$b19
000863462 7001_ $$0P:(DE-HGF)0$$aMcDougal, Robert A.$$b20
000863462 7001_ $$0P:(DE-HGF)0$$aSivagnanam, Subhashini$$b21
000863462 7001_ $$0P:(DE-HGF)0$$aSolinas, Sergio$$b22
000863462 7001_ $$0P:(DE-HGF)0$$aStanislovas, Rokas$$b23
000863462 7001_ $$0P:(DE-Juel1)138512$$avan Albada, Sacha$$b24
000863462 7001_ $$0P:(DE-HGF)0$$avan Geit, Werner$$b25
000863462 7001_ $$0P:(DE-HGF)0$$aSilver, R. Angus$$b26$$eCorresponding author
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