TY  - JOUR
AU  - Gleeson, Padraig
AU  - Cantarelli, Matteo
AU  - Marin, Boris
AU  - Quintana, Adrian
AU  - Earnshaw, Matt
AU  - Sadeh, Sadra
AU  - Piasini, Eugenio
AU  - Birgiolas, Justas
AU  - Cannon, Robert C.
AU  - Cayco-Gajic, N. Alex
AU  - Crook, Sharon
AU  - Davison, Andrew P.
AU  - Dura-Bernal, Salvador
AU  - Ecker, András
AU  - Hines, Michael L.
AU  - Idili, Giovanni
AU  - Lanore, Frederic
AU  - Larson, Stephen D.
AU  - Lytton, William W.
AU  - Majumdar, Amitava
AU  - McDougal, Robert A.
AU  - Sivagnanam, Subhashini
AU  - Solinas, Sergio
AU  - Stanislovas, Rokas
AU  - van Albada, Sacha
AU  - van Geit, Werner
AU  - Silver, R. Angus
TI  - Open Source Brain: A Collaborative Resource for Visualizing, Analyzing, Simulating, and Developing Standardized Models of Neurons and Circuits
JO  - Neuron
VL  - 103
IS  - 3
SN  - 0896-6273
CY  - New York, NY
PB  - Elsevier
M1  - FZJ-2019-03520
SP  - 395-411.e5
PY  - 2019
AB  - Computational models are powerful tools for exploring the properties of complex biological systems. In neuroscience, data-driven models of neural circuits that span multiple scales are increasingly being used to understand brain function in health and disease. But their adoption and reuse has been limited by the specialist knowledge required to evaluate and use them. To address this, we have developed Open Source Brain, a platform for sharing, viewing, analyzing, and simulating standardized models from different brain regions and species. Model structure and parameters can be automatically visualized and their dynamical properties explored through browser-based simulations. Infrastructure and tools for collaborative interaction, development, and testing are also provided. We demonstrate how existing components can be reused by constructing new models of inhibition-stabilized cortical networks that match recent experimental results. These features of Open Source Brain improve the accessibility, transparency, and reproducibility of models and facilitate their reuse by the wider community.
LB  - PUB:(DE-HGF)16
C6  - pmid:31201122
UR  - <Go to ISI:>//WOS:000479119400009
DO  - DOI:10.1016/j.neuron.2019.05.019
UR  - https://juser.fz-juelich.de/record/863462
ER  -