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@ARTICLE{Zlatopolskiy:863491,
      author       = {Zlatopolskiy, Boris and Endepols, Heike and Krapf, Philipp
                      and Guliyev, Mehrab and Urusova, Elizaveta A. and Richarz,
                      Raphael and Hohberg, Melanie and Dietlein, Markus and
                      Drzezga, Alexander and Neumaier, Bernd},
      title        = {{D}iscovery of 18{F}-{JK}-{PSMA}-7, a {PET} {P}robe for the
                      {D}etection of {S}mall {PSMA}-{P}ositive {L}esions},
      journal      = {Journal of nuclear medicine},
      volume       = {60},
      number       = {6},
      issn         = {2159-662X},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {FZJ-2019-03545},
      pages        = {817 - 823},
      year         = {2019},
      abstract     = {Prostate specific membrane antigen (PSMA) expressed by the
                      vast majority of prostate cancers (PCa) is a promising
                      target for PCa imaging. The application of PSMA specific
                      18F-labeled PET probes like 18F-DCFPyL and 18F-PSMA-1007
                      considerably improved the accuracy of PCa tumor detection.
                      However, there remains a need for further improvements
                      regarding sensitivity and specificity. The aim of this study
                      was the development of highly selective and specific PSMA
                      probes with enhanced imaging properties, in comparison with
                      18F-DCFPyL, 18F-PSMA-1007 and 68Ga-PSMA-11. Methods: Eight
                      novel 18F-labeled PSMA ligands were prepared. Their cellular
                      uptake in PSMA+ LNCaP C4-2 and PSMA– PC-3 cells was
                      compared to that of 18F-DCFPyL. The most promising
                      candidates were additionally evaluated by µPET in healthy
                      rats using PSMA+ peripheral ganglia as a model for small PCa
                      lesions. PET images of the ligand with the best outcome,
                      18F-JK-PSMA-7, were compared to those of 18F-DCFPyL,
                      18F-PSMA-1007 and 68GaPSMA-11 with respect to key image
                      quality parameters for the time frame 60-120 min. Results:
                      Compared to 18F-DCFPyL, 18F-JK-PSMA-7 demonstrated increased
                      PSMA specific cellular uptake. While target-to-background
                      ratios of 18F-DCFPyL and 18F-PSMA-1007 were comparable, this
                      parameter was higher for 18F-JK-PSMA-7 and lower for
                      68Ga-PSMA-11. Image acutance was significantly higher for
                      18F-JK-PSMA-7 and 18F-PSMA-1007 compared to 18F-DCFPyL and
                      68Ga-PSMA-11. Image resolution was similar for all four
                      tracers. 18F-PSMA-1007 demonstrated significantly higher
                      blood protein binding and bone uptake than the other
                      tracers. Conclusion: 18F-JK-PSMA-7 is a promising candidate
                      for high quality visualization of small PSMA-positive
                      lesions. Excellent preclinical imaging properties justify
                      further preclinical and clinical studies of this tracer.},
      cin          = {INM-5 / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30389823},
      UT           = {WOS:000470084400029},
      doi          = {10.2967/jnumed.118.218495},
      url          = {https://juser.fz-juelich.de/record/863491},
}