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@ARTICLE{Apetz:863492,
      author       = {Apetz, Nadine and Kordys, Elena and Simon, Mascha and Mang,
                      Britta and Aswendt, Markus and Wiedermann, Dirk and
                      Neumaier, Bernd and Drzezga, Alexander and Timmermann, Lars
                      and Endepols, Heike},
      title        = {{E}ffects of subthalamic deep brain stimulation on striatal
                      metabolic connectivity in a rat hemiparkinsonian model},
      journal      = {Disease models $\&$ mechanisms},
      volume       = {12},
      number       = {5},
      issn         = {1754-8411},
      address      = {Cambridge},
      publisher    = {Company of Biologists Limited},
      reportid     = {FZJ-2019-03546},
      pages        = {dmm039065 -},
      year         = {2019},
      abstract     = {Deep brain stimulation (DBS) in the subthalamic nucleus
                      (STN) has been successfully used for the treatment of
                      advanced Parkinson’s disease, although the underlying
                      mechanisms are complex and not well understood. There are
                      conflicting results about the effects of STN-DBS on neuronal
                      activity of the striatum, and its impact on functional
                      striatal connectivity is entirely unknown. We therefore
                      investigated how STN-DBS changes cerebral metabolic activity
                      in general and striatal connectivity in particular. We used
                      ipsilesional STN stimulation in a hemiparkinsonian rat model
                      in combination with [18F]FDOPA-PET, [18F]FDG-PET and
                      metabolic connectivity analysis. STN-DBS reversed
                      ipsilesional hypometabolism and contralesional
                      hypermetabolism in hemiparkinsonian rats by increasing
                      metabolic activity in the ipsilesional ventrolateral
                      striatum and by decreasing it in the contralesional
                      hippocampus and brainstem. Other STN-DBS effects were
                      subject to the magnitude of dopaminergic lesion severity
                      measured with [18F]FDOPA-PET, e.g. activation of the
                      infralimbic cortex was negatively correlated to lesion
                      severity. Connectivity analysis revealed that, in healthy
                      control animals, left and right striatum formed a bilateral
                      functional unit connected by shared cortical afferents,
                      which was less pronounced in hemiparkinsonian rats. The
                      healthy striatum was metabolically connected to the
                      ipsilesional substantia nigra in hemiparkinsonian rats only
                      (OFF condition). STN-DBS (ON condition) established a new
                      functional striatal network, in which interhemispheric
                      striatal connectivity was strengthened, and both the
                      dopamine-depleted and the healthy striatum were functionally
                      connected to the healthy substantia nigra. We conclude that
                      both unilateral dopamine depletion and STN-DBS affect the
                      whole brain and alter complex interhemispheric networks.},
      cin          = {INM-5 / INM-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31064773},
      UT           = {WOS:000470069500010},
      doi          = {10.1242/dmm.039065},
      url          = {https://juser.fz-juelich.de/record/863492},
}