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@ARTICLE{Ubben:863610,
      author       = {Ubben, Simon D. and Fink, Gereon R. and Kaesberg, Stephanie
                      and Kalbe, Elke and Kessler, Josef and Vossel, Simone and
                      Weiss, Peter H.},
      title        = {{D}eficient allo-centric visuospatial processing
                      contributes to apraxic deficits in sub-acute right
                      hemisphere stroke},
      journal      = {The journal of neuropsychology},
      volume       = {14},
      number       = {2},
      issn         = {1748-6645},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2019-03622},
      pages        = {242-259},
      year         = {2020},
      abstract     = {While visuospatial deficits are well‐characterized
                      cognitive sequelae of right hemisphere (RH ) stroke, apraxic
                      deficits in RH stroke remain poorly understood. Likewise,
                      very little is known about the association between apraxic
                      and visuospatial deficits in RH stroke or about the putative
                      common or differential pathophysiology underlying these
                      deficits. Therefore, we examined the behavioural and lesion
                      patterns of apraxic deficits (pantomime of object use and
                      bucco‐facial imitation) and visuospatial deficits (line
                      bisection and letter cancellation tasks) in 50 sub‐acute
                      RH stroke patients. Using principal component analysis (PCA
                      ), we characterized the relationship between the two
                      deficits. We hypothesized that any interaction of these
                      neuropsychological measures may be influenced by the demands
                      of ego‐centric/space‐based and/or
                      allo‐centric/object‐based processing. Contralesional
                      visuospatial deficits were common in our clinically
                      representative patient sample, affecting more than half of
                      RH stroke patients. Furthermore, about one‐third of all
                      patients demonstrated apraxic deficits. PCA revealed that
                      pantomiming and the imitation of bucco‐facial gestures
                      loaded clearly on a first component (PCA 1), while letter
                      cancellation loaded heavily on a second component (PCA 2).
                      For line bisection, overall mean deviation loaded on PCA 1,
                      while the difference between the mean deviations in
                      contra‐ versus ipsilesional space loaded on PCA 2. These
                      results suggest that PCA 1 represents
                      allo‐centric/object‐based processing and PCA 2
                      ego‐centric/space‐based processing. This interpretation
                      was corroborated by the statistical lesion analyses with the
                      component scores. Data suggest that disturbed
                      allo‐centric/object‐based processing contributes to
                      apraxic pantomime and imitation deficits in (sub‐acute) RH
                      stroke.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31207114},
      UT           = {WOS:000537120500004},
      doi          = {10.1111/jnp.12191},
      url          = {https://juser.fz-juelich.de/record/863610},
}