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000863612 1001_ $$0P:(DE-HGF)0$$aHoenig, Merle C.$$b0$$eCorresponding author
000863612 245__ $$aLevel of education mitigates the impact of tau pathology on neuronal function
000863612 260__ $$aHeidelberg [u.a.]$$bSpringer-Verl.$$c2019
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000863612 520__ $$aPurposeUsing PET imaging in a group of patients with Alzheimer’s disease (AD), we investigated whether level of education, a proxy for resilience, mitigates the harmful impact of tau pathology on neuronal function.MethodsWe included 38 patients with mild-to-moderate AD (mean age 67 ± 7 years, mean MMSE score 24 ± 4, mean years of education 14 ± 4; 20 men, 18 women) in whom a [18F]AV-1451 scan (a measure of tau pathology) and an [18F]FDG scan (a measure of neuronal function) were available. The preprocessed PET scans were z-transformed using templates for [18F]AV-1451 and [18F]FDG from healthy controls, and subsequently thresholded at a z-score of ≥3.0, representing an one-tailed p value of 0.001. Next, three volumes were computed in each patient: the tau-specific volume (tau pathology without neuronal dysfunction), the FDG-specific volume (neuronal dysfunction without tau pathology), and the overlap volume (tau pathology and neuronal dysfunction). Mean z-scores and volumes were extracted and used as dependent variables in regression analysis with years of education as predictor, and age and MMSE score as covariates.ResultsYears of education were positively associated with tau-specific volume (β = 0.362, p = 0.022), suggesting a lower impact of tau pathology on neuronal function in patients with higher levels of education. Concomitantly, level of education was positively related to tau burden in the overlap volume (β = 0.303, p = 0.036) implying that with higher levels of education more tau pathology is necessary to induce neuronal dysfunction.ConclusionIn patients with higher levels of education, tau pathology is less paralleled by regional and remote neuronal dysfunction. The data suggest that early life-time factors such as level of education support resilience mechanisms, which ameliorate AD-related effects later in life.
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000863612 7001_ $$0P:(DE-HGF)0$$aBischof, Gérard N.$$b1
000863612 7001_ $$0P:(DE-Juel1)131736$$aOnur, Özgür A.$$b2$$ufzj
000863612 7001_ $$0P:(DE-HGF)0$$aKukolja, Juraj$$b3
000863612 7001_ $$0P:(DE-HGF)0$$aJessen, Frank$$b4
000863612 7001_ $$0P:(DE-HGF)0$$aFliessbach, Klaus$$b5
000863612 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b6$$ufzj
000863612 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b7$$ufzj
000863612 7001_ $$0P:(DE-HGF)0$$aKalbe, Elke$$b8
000863612 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b9$$ufzj
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000863612 773__ $$0PERI:(DE-600)2098375-X$$a10.1007/s00259-019-04342-3$$n9$$p1787–1795 $$tEuropean journal of nuclear medicine and molecular imaging$$v46$$x1619-7089$$y2019
000863612 8564_ $$uhttps://juser.fz-juelich.de/record/863612/files/Hoenig2019_Article_LevelOfEducationMitigatesTheIm.pdf$$yRestricted
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000863612 8564_ $$uhttps://juser.fz-juelich.de/record/863612/files/Hoenig_2019_Post%20Print_EJNMMI_Level%20of%20Education%20Mitigates%20the%20Impact%20of%20Tau-Pathology%20on%20Neuronal%20Function.pdf$$yPublished on 2019-06-10. Available in OpenAccess from 2020-06-10.
000863612 8564_ $$uhttps://juser.fz-juelich.de/record/863612/files/Hoenig_2019_Post%20Print_EJNMMI_Level%20of%20Education%20Mitigates%20the%20Impact%20of%20Tau-Pathology%20on%20Neuronal%20Function.pdf?subformat=pdfa$$xpdfa$$yPublished on 2019-06-10. Available in OpenAccess from 2020-06-10.
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