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@ARTICLE{Weis:863624,
author = {Weis, Susanne and Patil, Kaustubh R and Hoffstaedter, Felix
and Nostro, Alessandra and Yeo, B T Thomas and Eickhoff,
Simon B},
title = {{S}ex {C}lassification by {R}esting {S}tate {B}rain
{C}onnectivity},
journal = {Cerebral cortex},
volume = {30},
number = {2},
issn = {1460-2199},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {FZJ-2019-03635},
pages = {824-835},
year = {2020},
note = {The Deutsche Forschungsgemeinschaft (EI 816/11-1),
TheNational Institute of Mental Health (R01-MH074457);
TheHelmholtz Portfolio Theme “Supercomputing and Modeling
forthe Human Brain”; The European Union [Horizon 2020
Researchand Innovation Programme under grant agreement no.
720270(HBP SGA1) 785907 (HBP SGA2)]; Singapore National
ResearchFoundation [fellowship (class of 2017) to
B.T.T.Y.].APC $\&$ Rechnung ergänzt 10.07.19},
abstract = {A large amount of brain imaging research has focused on
group studies delineating differences between males and
females with respect to both cognitive performance as well
as structural and functional brain organization. To
supplement existing findings, the present study employed a
machine learning approach to assess how accurately
participants' sex can be classified based on spatially
specific resting state (RS) brain connectivity, using 2
samples from the Human Connectome Project (n1 = 434,
n2 = 310) and 1 fully independent sample from the
1000BRAINS study (n = 941). The classifier, which was
trained on 1 sample and tested on the other 2, was able to
reliably classify sex, both within sample and across
independent samples, differing both with respect to imaging
parameters and sample characteristics. Brain regions
displaying highest sex classification accuracies were mainly
located along the cingulate cortex, medial and lateral
frontal cortex, temporoparietal regions, insula, and
precuneus. These areas were stable across samples and match
well with previously described sex differences in functional
brain organization. While our data show a clear link between
sex and regionally specific brain connectivity, they do not
support a clear-cut dimorphism in functional brain
organization that is driven by sex alone.},
cin = {INM-7},
ddc = {610},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {571 - Connectivity and Activity (POF3-571) / SMHB -
Supercomputing and Modelling for the Human Brain
(HGF-SMHB-2013-2017) / HBP SGA2 - Human Brain Project
Specific Grant Agreement 2 (785907)},
pid = {G:(DE-HGF)POF3-571 / G:(DE-Juel1)HGF-SMHB-2013-2017 /
G:(EU-Grant)785907},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:31251328},
UT = {WOS:000530440700031},
doi = {10.1093/cercor/bhz129},
url = {https://juser.fz-juelich.de/record/863624},
}