TY  - JOUR
AU  - Dasanna, Anil K.
AU  - Fedosov, Dmitry A.
AU  - Gompper, Gerhard
AU  - Schwarz, Ulrich S.
TI  - State diagram for wall adhesion of red blood cells in shear flow: from crawling to flipping
JO  - Soft matter
VL  - 15
IS  - 27
SN  - 1744-6848
CY  - London
PB  - Royal Soc. of Chemistry
M1  - FZJ-2019-03769
SP  - 5511 - 5520
PY  - 2019
AB  - Red blood cells in shear flow show a variety of different shapes due to the complex interplay between hydrodynamics and membrane elasticity. Malaria-infected red blood cells become generally adhesive and less deformable. Adhesion to a substrate leads to a reduction in shape variability and to a flipping motion of the non-spherical shapes during the mid-stage of infection. Here, we present a complete state diagram for wall adhesion of red blood cells in shear flow obtained by simulations, using a particle-based mesoscale hydrodynamics approach, multiparticle collision dynamics. We find that cell flipping at a substrate is replaced by crawling beyond a critical shear rate, which increases with both membrane stiffness and viscosity contrast between the cytosol and suspending medium. This change in cell dynamics resembles the transition between tumbling and tank-treading for red blood cells in free shear flow. In the context of malaria infections, the flipping–crawling transition would strongly increase the adhesive interactions with the vascular endothelium, but might be suppressed by the combined effect of increased elasticity and viscosity contrast.
LB  - PUB:(DE-HGF)16
C6  - pmid:31241632
UR  - <Go to ISI:>//WOS:000477949700005
DO  - DOI:10.1039/C9SM00677J
UR  - https://juser.fz-juelich.de/record/863773
ER  -