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@ARTICLE{Dasanna:863773,
author = {Dasanna, Anil K. and Fedosov, Dmitry A. and Gompper,
Gerhard and Schwarz, Ulrich S.},
title = {{S}tate diagram for wall adhesion of red blood cells in
shear flow: from crawling to flipping},
journal = {Soft matter},
volume = {15},
number = {27},
issn = {1744-6848},
address = {London},
publisher = {Royal Soc. of Chemistry},
reportid = {FZJ-2019-03769},
pages = {5511 - 5520},
year = {2019},
abstract = {Red blood cells in shear flow show a variety of different
shapes due to the complex interplay between hydrodynamics
and membrane elasticity. Malaria-infected red blood cells
become generally adhesive and less deformable. Adhesion to a
substrate leads to a reduction in shape variability and to a
flipping motion of the non-spherical shapes during the
mid-stage of infection. Here, we present a complete state
diagram for wall adhesion of red blood cells in shear flow
obtained by simulations, using a particle-based mesoscale
hydrodynamics approach, multiparticle collision dynamics. We
find that cell flipping at a substrate is replaced by
crawling beyond a critical shear rate, which increases with
both membrane stiffness and viscosity contrast between the
cytosol and suspending medium. This change in cell dynamics
resembles the transition between tumbling and tank-treading
for red blood cells in free shear flow. In the context of
malaria infections, the flipping–crawling transition would
strongly increase the adhesive interactions with the
vascular endothelium, but might be suppressed by the
combined effect of increased elasticity and viscosity
contrast.},
cin = {ICS-2},
ddc = {530},
cid = {I:(DE-Juel1)ICS-2-20110106},
pnm = {552 - Engineering Cell Function (POF3-552)},
pid = {G:(DE-HGF)POF3-552},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:31241632},
UT = {WOS:000477949700005},
doi = {10.1039/C9SM00677J},
url = {https://juser.fz-juelich.de/record/863773},
}