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@ARTICLE{Reichel:863774,
      author       = {Reichel, Felix and Mauer, Johannes and Nawaz, Ahmad Ahsan
                      and Gompper, Gerhard and Guck, Jochen and Fedosov, Dmitry
                      A.},
      title        = {{H}igh-{T}hroughput {M}icrofluidic {C}haracterization of
                      {E}rythrocyte {S}hapes and {M}echanical {V}ariability},
      journal      = {Biophysical journal},
      volume       = {117},
      number       = {1},
      issn         = {0006-3495},
      address      = {Bethesda, Md.},
      publisher    = {Soc.},
      reportid     = {FZJ-2019-03770},
      pages        = {14 - 24},
      year         = {2019},
      abstract     = {The motion of red blood cells (RBCs) in microchannels is
                      important for microvascular blood flow and biomedical
                      applications such as blood analysis in microfluidics. The
                      current understanding of the complexity of RBC shapes and
                      dynamics in microchannels is mainly based on several
                      simulation studies, but there are a few systematic
                      experimental investigations. Here, we present a combined
                      study that systematically characterizes RBC behavior for a
                      wide range of flow rates and channel sizes. Even though
                      simulations and experiments generally show good agreement,
                      experimental observations demonstrate that there is no
                      single well-defined RBC state for fixed flow conditions but
                      rather a broad distribution of states. This result can be
                      attributed to the inherent variability in RBC mechanical
                      properties, which is confirmed by a model that takes the
                      variation in RBC shear elasticity into account. This
                      represents a significant step toward a quantitative
                      connection between RBC behavior in microfluidic devices and
                      their mechanical properties, which is essential for a
                      high-throughput characterization of diseased cells.},
      cin          = {ICS-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-2-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31235179},
      UT           = {WOS:000474550400004},
      doi          = {10.1016/j.bpj.2019.05.022},
      url          = {https://juser.fz-juelich.de/record/863774},
}