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@ARTICLE{SchottVerdugo:863890,
      author       = {Schott-Verdugo, Stephan and Müller, Lena and Classen,
                      Elisa and Gohlke, Holger and Groth, Georg},
      title        = {{S}tructural {M}odel of the {ETR}1 {E}thylene {R}eceptor
                      {T}ransmembrane {S}ensor {D}omain},
      journal      = {Scientific reports},
      volume       = {9},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2019-03861},
      pages        = {8869},
      year         = {2019},
      abstract     = {The structure, mechanism of action and copper stoichiometry
                      of the transmembrane sensor domain of the plant ethylene
                      receptor ETR1 and homologs have remained elusive, hampering
                      the understanding on how the perception of the plant hormone
                      ethylene is transformed into a downstream signal. We
                      generated the first structural model of the transmembrane
                      sensor domain of ETR1 by integrating ab initio structure
                      prediction and coevolutionary information. To refine and
                      independently validate the model, we determined
                      protein-related copper stoichiometries on purified receptor
                      preparations and explored the helix arrangement by
                      tryptophan scanning mutagenesis. All-atom molecular dynamics
                      simulations of the dimeric model reveal how ethylene can
                      bind proximal to the copper ions in the receptor,
                      illustrating the initial stages of the ethylene perception
                      process.},
      cin          = {ICS-6 / JSC / NIC},
      ddc          = {600},
      cid          = {I:(DE-Juel1)ICS-6-20110106 / I:(DE-Juel1)JSC-20090406 /
                      I:(DE-Juel1)NIC-20090406},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511) / Forschergruppe Gohlke $(hkf7_20170501)$},
      pid          = {G:(DE-HGF)POF3-511 / $G:(DE-Juel1)hkf7_20170501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31222090},
      UT           = {WOS:000472136900043},
      doi          = {10.1038/s41598-019-45189-w},
      url          = {https://juser.fz-juelich.de/record/863890},
}